Effect of Methanolic Extract of Passiflora foetida on Glucose Kinetics in Alloxan-induced Diabetic Mice
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 14, Issue 1
Abstract
Background: This study investigated the hypoglycemic potential of methanolic extract of Passiflora foetida (PF) in alloxan-induced diabetic albino mice. Diabetes is a metabolic disease characterized with high blood sugar levels over a prolonged period. Discovery of a new drug will greatly reduce the mortality and morbidity associated with the disease. Methods: Diabetes was induced in albino mice by administration of 150 mg/kg body weight (b.w.) alloxan. Different concentrations of the methanolic extract of PF was prepared and administered orally to groups of alloxan-induced diabetic mice. Blood glucose was determined at different time points over 4 hrs. Results: The extract reduced blood glucose levels in diabetic mice significantly (P<0.001) and the kinetic parameters such as, area under glucose concentration time curve (AUC0-4hG) (P<0.05), glucose mean residence time (MRTG), glucose t1/2G were significantly lower (<0.05) in PF treated groups when compared with the control groups. The rate of glucose clearance (CLG) was high in the group treated with the extract. Conclusion: The results of this study indicate presence of hypoglycemic constituent in the plant.
Authors and Affiliations
A. O. Sijuade
Keywords
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- EP ID EP339932
- DOI 10.9734/BJMMR/2016/23767
- Views 38
- Downloads 0
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