EFFECT OF NON IONIC SURFACTANT ON THE SOLUBILITY AND DISSOLUTION OF SIMVASTATIN
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
Various investigators have been facing the problems in improving solubility, dissolution and bioavailability of poorly water soluble drugs. Solid dispersion is a unique approach to improve the solubility of poorly water soluble drugs. In the present study an attempt has been made to improve the solubility and dissolution of poorly soluble drug Simvastatin (SIM) using Poloxamer 188 (PXM) as carrier. The kneading technique was used to prepare solid dispersions in different ratios. In conclusion, solubility and dissolution enhancement of SIM was improved by preparing its solid dispersion with PXM.
Authors and Affiliations
Sandeep Kumar , Suresh Purohit , G D Gupta
Keywords
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