EFFECT OF POLYMERS AND GAS FORMING AGENTS ON GASTRO RETENTIVE FLOATING TABLETS OF ATORVASTATIN CALCIUM
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2012, Vol 2, Issue 4
Abstract
Atorvastatin Calcium is a lipid lowering drug. It is a HMG-CoA reductase inhibitor used in the treatment of hyper lipidaemia. It has a oral bioavailability of less than 12% Floating matrix tablets are designed to prolong the gastric residence time after oral administration, at a particular site and controlling the release of drug, especially useful for achieving controlled plasma level as well as improving bioavailability. With this objective, floating dosage form containing Atorvastatin Calcium as drug was designed. Tablets containing hydroxypropylmethylcellulose (HPMC), drug and different additives were compressed using wet granulation. The study shows that tablet composition has great influence on the floating properties and drug release. Incorporation of gas-generating agent together with polymer improved drug release, besides optimal floating (floating lag time ~30 s; total floating time >12 h). The drug release was sufficiently sustained (more than 11h) and non-Fickian as well as zero-order was confirmed.
Authors and Affiliations
Manivannan R, Krishnarajan D, Asirdhayan J, Gowthaman R, Senthilkumar N
Keywords
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