Effect of raloxifene on alveolar bone resorption after mucoperiosteal flap surgery in mice
Journal Title: Stomatos - Year 2015, Vol 21, Issue 41
Abstract
Background: Mucoperiosteal flap surgeries (MFS) are carried out to provide access to the alveolar bone and root surfaces in several clinical situations. Nevertheless, they lead to a variable degree of alveolar bone resorption. Raloxifene is an agonist in bone, and acts inhibiting bone loss. Objective: To evaluate the effect of raloxifene in preventing alveolar bone resorption after MFS using an experimental model of mouse mandibles. Methods: MFS was performed on the buccal aspect of the left side of the mandible (BL) in 20 male CF1 Musdomesticus mice divided into two groups with the same number of animals: the experimental group was treated once daily with raloxifene injections (3 mg/kg), and the placebo group was treated with daily injections of the vehicle. The buccal aspects of right hemimandibles were used as controls (BR). Mandibles were removed, defleshed and stained with toluidine blue in a stereomicroscope. Digital images were obtained and the alveolar bone loss was measured (mm2) using an image analysis software. Results: The BL area exhibited significantly more bone loss (Student t test; p < 0.01) when compared to the BR area, in both groups. No statistically significant difference was observed between the experimental and the placebo groups. Conclusion: In this study, raloxifene did not inhibit alveolar bone resorption following MFS in male mice.
Authors and Affiliations
Cristiane Alencar, Dalva Maria Pereira Padilha, Luis Carlos F. Frasca, Daiane Cerutti-Kopplin, Sabrina Rebollo Zani, Elken G. Rivaldo
Keywords
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