Effect of Rosuvastatin on Lumbar Radicular Pain: A Prospective Pilot Study
Journal Title: The 2nd Annual Meeting of International Center for Neuroscience Research - Year 2021, Vol 2, Issue 1
Abstract
Neuropathic pain is a debilitating condition caused by a lesion or disease of the somatosensory nervous system. effective management of neuropathic pain is difficult. There are several medications for controlling pain syndromes but sometimes they have limited effects on the painful conditions. Neuropathic pain represents an area of substantial need for novel therapeutics or novel therapeutic application of other currently used drugs. Statins are a well-established class of drugs that lower plasma cholesterol levels by inhibiting HMG-CoA (3-hydroxy-3- methyl-glutaryl-coenzyme A) reductase. They exhibit pleiotropic cholesterol-independent effects, e.g., antiinflammatory and neuromodulatory effects. Preclinical studies showed dichotomous responses of statins. Both pain-attenuating and pain-inducing effects are seen. Some studies indicate that the pain-inducing effect is seen at the higher doses. in this study, patients were devided into three groups. The first group received gabapentin 100 mg/d at bed time, the second group received rosuvastatin 10 mg/d at bed time, and the third group received naproxen 250 mg/bid. Severity of pain and neuropathic pain were assessed by NRS and DN4 questionnaires. All three groups consisted of 10 patients suffering from low back pain with sciatica. Inclusion criteria were: 1) age between 20 and 80 years, 2) no neurologic and infectious etiology for the pain, 3) chronic pain more than 3 months, and 4) NRS score greater than 4. Written consent from all patients were obtained. The effect of rosuvastatin is comparable to the other routinely used medications. All three groups showed significant (p value<0.001) improvement in pain scores after treatment. between groups comparison showed no signigicant differences. We have shown that statins have the potential to be effective for pain reduction in chronic radiating lumbosacral pain. It warrants further investigation, including larger placebo-controlled and noninferiority studies, and quality-of-life comparisons. Longer-term studies are also warranted to evaluate the duration of efficacy as well as side effects of statins.
Authors and Affiliations
Sasan Gazerani and Sanaz Sha’abani*
Keywords
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