Effect of Saudi and Egyptian Pomegranate Polyphenols in Regulating the Activity of Pon1, Pon2 and Lipid Profile for Preventing Coronary Heart Disease
Journal Title: Journal of Regenerative Biology and Medicine - Year 2019, Vol 1, Issue 1
Abstract
Saudi and Egyptian pomegranate juice (APJ and EPJ) contains potent polyphenols, antioxidants that were found to reduce serum and macrophage oxidative stress. The protective effects of APJ and EPJ against atherogenicity were evaluated by feeding mice a hypercholesterolemic diet that was supplemented with PJ.PJ consumption reduced mice serum triglycerides (TG), total cholesterol (TC) and (low density lipoprotein (LDL-c) and increased the high-density lipoprotein (HDL-c) when compared to mice with a control or atherogenic diet. The risk ratio and atherogenic index were significantly lower in both APJ or EPJ supplemented groups. Paraoxonase 1 (PON1), which remains associated with HDL, had a significant increase in activity in mice supplemented with PJ, compared to mice with aatherogenic diet (AD). PJ consumption significantly reduced lipid peroxidation and increased glutathione levels. The reduction in lipid peroxidation varied from 57 to 76%. PJ supplementation reduced peritoneal macrophage (MPM)-mediated oxidation of LDL by 68 to 82% and decreased mouse MPM Ox-LDL uptake by 31 to 48%. A significant up-regulation of macrophage PON2 activity was induced by PJ reducing the macrophage oxidative stress. In conclusion, PJ consumption resulted in anti-oxidative and anti-atherogenic effect on serum and macrophages, which could prevent atherosclerosis and coronary heart diseases.
Authors and Affiliations
Mona Nasser BinMowyna1, Manal Abdulaziz Binobead2, Nawal Abdullah Al Badr2, Sahar Abdulaziz AlSedairy2, Islam Abdul Rahim Elredh3, Wedad Saeed Alqahtani4*
Keywords
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- EP ID EP707303
- DOI https://doi.org/10.37191/Mapsci-2582-385X-1(1)-003
- Views 85
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