Effect of simvastatin versus metformin on biochemical profile of polycystic ovary syndrome: a randomized clinical trial
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2014, Vol 8, Issue 11
Abstract
Background: Metformin has been widely investigated for treating Polycystic ovary syndrome(PCOS), however, it doesn’t improve total biochemical profile of the disorder. The aim of this study was to assess the efficacy of simvastatin on PCOS and to compare its effect with metformin on biochemical and clinical symptoms of polycystic ovary syndrome.Methods: In a randomized clinical trial 60 women at reproductive age with PCOS were allocated to receive either 1500 mg dose of metformin tablets, or simvastatin tablets in 20 mg daily dosage. Several lipid, carbohydrate and steroid profile assessments were done at baseline and three months afterwards.Results: In this study Fasting blood sugar(FBS), serum insulin, menstrual cycle irregularities and hyperinsulinemia decreased significantly after treatment with metformin. Moreover, cholesterol, LDL, HDL, DHEAS, hyperinsulinemia, acne, and positive CRP tests decreased significantly in simvastatin group. Conclusion: Biochemical pattern of PCOS is differently affected by metformin and simvastatin and a complementary efficacy of combined treatment may also be anticipated.
Authors and Affiliations
Shabnam Pourabolghasem| Women’s reproductive health research center, Tabriz University of medical sciences, Tabriz, Iran, Nazli Navali*| Women’s reproductive health research center, Tabriz University of medical sciences, Tabriz, Iran, email: Navali2014@gmail.com, Parvin Bastani| Women’s reproductive health research center, Tabriz University of medical sciences, Tabriz, Iran, Fatemeh Kazemivand| Women’s reproductive health research center, Tabriz University of medical sciences, Tabriz, Iran
Keywords
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