EFFECT OF TELMISARTAN AND RUTIN IN ALCOHOL PLUS HIGH FRUCTOSE DIET INDUCED METABOLIC DYSFUNCTION IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 12
Abstract
The objective of the study was to investigate the effect of telmisartan and rutin in High Fructose Diet plus alcohol induced metabolic syndrome in rats. Our study demonstrated the beneficial effects of telmisartan and rutin on both abnormal metabolic characters and vascular dysfunction in insulin resistant rats. Initially we have validated the pre diabetic metabolic syndrome rat model by feeding high fructose diet to the male Sprague Dawley rats. Development of metabolic syndrome and glucose intolerance was assessed by performing the plasma biochemical analysis such as plasma glucose, triglyceride, insulin and total cholesterol levels. Glucose intolerance was assessed by performing an intra peritoneal glucose tolerance test and Histopathological studies of Liver were conducted. In the present study, we examined the effect telmisartan and rutin and the relationship between the plasma adiponectin concentration and adiposity, body fat distribution, lipid profile, renal profile, liver enzymes, Cardio vascular parameters, histopathology of Liver, in high fructose diet fed Sprague-dawley rats. It was concluded that telmisartan and rutin are effective in treating metabolic dysfunction and alcohol induced liver toxicity Further studies are needed to explore the underlying mechanisms.
Authors and Affiliations
Lal Mahammed, P. Sireesha, E. Supraja, B. Pooja
Keywords
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- EP ID EP110017
- DOI 10.7897/2230-8407.041213
- Views 159
- Downloads 0
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