EFFECT OF THE PREPARATION OF SOLID DISPERSION METHOD ON THE SOLUBILITY AND CRYSTALLINITY OF SULFASALAZINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 4
Abstract
The solubility, dissolution and physicochemical properties of the sulfasalazine in the three solid dispersions were evaluated compared to drug powder using Scanning electron microscopy, differential scanning colorimetric and powder X-ray diffraction. Three solid dispersions containing poorly water-soluble sulfasalazine were prepared with hydroxypropyl-β-cyclodextrin (HP-β-CD) and dioctyl sulfosuccinate. The solubility and dissolution of the drug were significantly improved in the order of the sulfasalazine-loaded solid dispersion prepared by: solvent-evaporation method > solvent-wetting method > surface-attached method. The solid dispersions prepared by solvent evaporation appeared as an aggregated form with the amorphous form. In particular, the solid dispersion prepared by the solvent-evaporation method improved solubility about 900-fold. The solid dispersion prepared by the surface-attached method gave an unchanged crystalline form. In this solid dispersion, the carriers were attached to the surface of the undissolved drug. Thus, in the development of a solid-dispersion system containing poorly water-soluble drugs, the method of preparation plays an important role in the solubility and crystallinity of the drugs.
Authors and Affiliations
Rajesh Asija , Sangeeta Asija , H. S. Lamba , Anil Bhandari , Sandeep Kataria
Keywords
Related Articles
- EP ID EP103238
- DOI -
- Views 277
- Downloads 0
INDUSTRIAL PROCESS VALIDATION OF SOLID ORAL DASAGE FORM: A REVIEW
Validation is the important step in gaining and maintaining the quality of the final product. Validation of the individual steps of the processes is called the process validation. Different dosage forms have different va...
A VALIDATED RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF FLUOXETINE HYDROCHLORIDE AND OLANZAPINE IN PHARMACEUTICAL DOSAGE FORM
A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Fluoxetine hydrochloride and Olanzapine in pharmaceutical dosage forms. T...
FORMULATION AND IN VITRO EVALUATION OF LOVASTATIN BUCCAL TABLETS
The present investigation is concerned with formulation and in-vitro evaluation of mucoadhesive buccal tablets containing anticholesteremic agent. Lovastatin to by-pass the first pass effect and to improve its bio availa...
FISHES OF MADHYA PRADESH WITH SPECIAL REFERENCE TO ZEBRAFISH AS MODEL ORGANISM IN BIOMEDICAL RESEARCHES
Many surveys on fish species found in reservoirs, rivers, ponds or collection centres of Madhya Pradesh (MP) have been done during recent years. Fish are palatable and proteinous food for human beings. India is now at th...
BIPHENYL SUBSTITUTED CONSTITUENTS FROM THE RHIZOMES OF CURCUMA AMADA ROXB.
Phytochemical investigation of the rhizomes of Curcuma amada Roxb. (Zingiberaceae) led to isolation of three new biphenyl substituted hydrocarbons identified as 1- (3’, 4’-dihydroxyphenyl)-8 - ( 3’’, 4’’ - dimethoxy - 5’...