EFFECT OF THE PREPARATION OF SOLID DISPERSION METHOD ON THE SOLUBILITY AND CRYSTALLINITY OF SULFASALAZINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 4
Abstract
The solubility, dissolution and physicochemical properties of the sulfasalazine in the three solid dispersions were evaluated compared to drug powder using Scanning electron microscopy, differential scanning colorimetric and powder X-ray diffraction. Three solid dispersions containing poorly water-soluble sulfasalazine were prepared with hydroxypropyl-β-cyclodextrin (HP-β-CD) and dioctyl sulfosuccinate. The solubility and dissolution of the drug were significantly improved in the order of the sulfasalazine-loaded solid dispersion prepared by: solvent-evaporation method > solvent-wetting method > surface-attached method. The solid dispersions prepared by solvent evaporation appeared as an aggregated form with the amorphous form. In particular, the solid dispersion prepared by the solvent-evaporation method improved solubility about 900-fold. The solid dispersion prepared by the surface-attached method gave an unchanged crystalline form. In this solid dispersion, the carriers were attached to the surface of the undissolved drug. Thus, in the development of a solid-dispersion system containing poorly water-soluble drugs, the method of preparation plays an important role in the solubility and crystallinity of the drugs.
Authors and Affiliations
Rajesh Asija , Sangeeta Asija , H. S. Lamba , Anil Bhandari , Sandeep Kataria
Keywords
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