Effect of varying glycated hemoglobin level on lipid profile in patients with type 2 diabetes
Journal Title: Scholars Academic Journal of Biosciences - Year 2017, Vol 5, Issue 8
Abstract
Chronic hyperglycemia in diabetic patients is often associated with long term complications like diabetic nephropathy, neuropathy, retinopathy and heart diseases. An abnormal lipid level is considered as the most common factor for heart disease and is responsible for higher mortality due to its complications. Now, glycated hemoglobin (HbA1c) has been accepted as a biochemical marker for long term blood glucose concentration and also a measure for development of complications caused due to diabetes mellitus. For every rise in 1% of absolute HbA1c the possibility of having heart diseases increases by 18% hence, rigid glycemic control with HbA1c <7% is recommended for the diabetic patients. This study was designed to compare the lipid profile levels in patients with type 2 diabetes mellitus not on lipid lowering drugs depending on their HbA1c levels.One hundred and ten patients of type 2 diabetes mellitus were divided into four groups based on their HbA1c levels: HbA1c ≤ 6.9% (n= 20), HbA1c 7-8.4% (n= 40), HbA1c 8.5 – 9.9% (n= 15) and HbA1c ≥ 10% (n= 35). Fasting lipid profile was estimated by dry chemistry analyzer (Vitros 250) and HbA1c was estimated by high performance liquid chromatography (Biorad D10).In our study, we found that patients with HbA1c level ≥10% i.e., very poor glycemic control had significantly lower good cholesterol (HDL) levels. Also, LDL/ HDL and TC/ HDL ratios were higher in patients with very poor glycemic control.The findings of our study indicate that type 2 diabetic patients with HbA1c ≥ 10% are at higher risk of developing cardiovascular diseases. Timely intervention can prevent complications due to diabetes by strictly monitoring lipid profile along with HbA1c levels.
Authors and Affiliations
Kalpana Singh, Tuba Afsheen, Bhawna Mahajan, Jitendra Rao, Abbas Ali Mahdi
Keywords
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