Effectiveness and Safety of Topical Emollients in the Treatment of PUVA-Induced Pruritus
Journal Title: Advances in Clinical and Experimental Medicine - Year 2013, Vol 22, Issue 5
Abstract
<strong>Background</strong>. In this study we tried to assess the efficacy of topical emollients in the treatment of patients with PUVA-induced pruritus.<br /><strong>Material and Methods</strong>. 41 patients over 18 years of age, who received PUVA treatment in the phototherapy unit, were included in the study. Patients were randomly divided into two groups; Group I was administered with a 4% urea lotion and Group II was administered with liquid petrolatum. The follow-up period was minimum 4 weeks. During the first 2 weeks, patients were administered topical emollients and received PUVA treatment together. The next 2 weeks, they continued PUVA treatment without any medication.<br /><strong>Results</strong>. When time-dependent changes in the visual analogue scale scores for pruritus of both groups were considered, both treatment methods were found to be remarkably successful (p < 0.0001). In addition, an insignificant group-time interaction was identified (p = 0.753).<br /><strong>Conclusions</strong>. Topical emollients were found to be effective in the treatment of PUVA-induced pruritus. Both forms of medication can be successfully administered and increase the patient’s compliance with medication.
Authors and Affiliations
Enver Turan, Mehmet Gurel, Asli Erdemir, Murat Usta, Nurdan Kutlu
Keywords
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