EFFECTIVENESS OF ANTIHYPERTENSIVE AGENTS AMONG HYPERTENSIVE PATIENTS OF NEPAL
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 12
Abstract
These investigations compare the effectiveness of antihypertensive agents among hypertensive patients. It was an open label, prospective and comparative study carried out in the Out-patient department at BPKIHS, Dharan, Sunsari, Nepal. Patients of either sex aged between 25-80 years suffering from mild to moderate hypertension were randomly selected. In this study indicate various types of antihypertensive drugs for the management of hypertension like Calcium channel blockers (amlodipine), Angiotensin Converting enzyme inhibitors (Enalpril), beta adrenergic blocker (metoprolol, propranolol, atenolol), Angiotension receptor blocker (Losartan), Diuretics (Spironolactone, Furesomide). In this study, out of 40 patients of stage 1 hypertension: 18 % patients were treated with ARBs, 30 % patients were treated with CCBs, 15 % patients with CCBs + diuretics, 8 % patients with β- blockers + ARBs, 10 % with ACE inhibitors and 12.5 % patients were treated with β – blockers + CCBs. Similarly, out of 15 patients of stage 2 hypertensive patients, 6 % patients were treated with ARBs + diuretics, 13 % patients with ARBs + β blockers, 20 % with CCBs + diuretics, 20 % with β blockers + ACE inhibitors and 40 % patients were treated with CCBs + ARBs. Three drug combined therapy is more effective as compared to two drug combined therapy and mono therapy. In this study, male hypertensive patients were observed more susceptible with severe hypertension as compared to female hypertensive patients. The reason corresponding to this statement might be more stressful life style and frequent smoking habit as well as more alcohol consumption habit of male as compared to female.
Authors and Affiliations
Subash Pandaya, Md. Reyad-ul-ferdous, Vijay Panthi, Manson Pandey, Laxman Maharjan
Keywords
Related Articles
- EP ID EP94800
- DOI 10.7897/2230-8407.0512183
- Views 114
- Downloads 0
ANALYSIS OF PHYTOCHEMICAL COMPOSITION AND BACTERIOSTATIC ACTIVITY OF TAGETES SP
Present study was carried out to investigate the antimicrobial effect of ethanolic extracts of leaves and flowers of Tagetes erecta Linn and Tagetes patula Linn. After performing preliminary phytochemical screening and...
IMMUNOLOGICAL STUDY OF SPONGIFORM ENCEPHALOPATHIES
Spongiform encephalopathies, categorized as a subclass of neuro-degenerative diseases and commonly known as prion diseases, are a group of progressive conditions that affect the brain and nervous system of many animals,...
AN OVERVIEW ON SYMPTOMS CAUSES TEST TREATMENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Chronic obstructive pulmonary disease (COPD) has a dramatic effect on quality of life. The need to formulate a different set of parameters for peoples was felt because of the differences in risk factors, disease prevalen...
PREPARATION AND EVALUATION OF COLON SPECIFIC IBUPROFEN TABLETS
The aim of the present study was done to evaluate drug release at the colon specific region by developing the formula which can deliver the drug at the colonic region of the GIT. For this particular study the pelletizati...
DRY GRANULATION TECHNIQUE FOR CONVERTING TRIPHALA CHURNA AS GRANULES, TABLETS AND ORGANOLEPTIC EVALUATION
The objective of this research work was the conversion of Triphala churna into stable, palatable and patient acceptable granules to swallow conveniently by dry granulation methods, using suitable binding agents. The chur...