Effectiveness of Misoprostol for the Prevention of Postpartum Haemorrhage: A Review
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 3
Abstract
Postpartum haemorrhage (PPH) is the major cause of maternal morbidity and mortality globally. Prevention of PPH will reduce the number of maternal deaths in rural communities of developing countries. This study aim to access evidence on the effectiveness of misoprostol compared to oxytocin or placebo, and to explore the optimal dose and the best route of administration for the prevention of PPH. The MEDLINE, CINAHL, Science Direct, Intermid and the Cochrane Library were systematically searched. Studies that compared misoprostol and oxytocin or placebo for the prevention of PPH were selected following inclusion and exclusion criteria. Also, hand-searches of 7 Journals and citations tracking were employed. A total of 16 articles that met the inclusion criteria were selected and used for this review. Among the 16 studies included in the review, misoprostol was found to be as effective as oxytocin in the prevention of PPH in developing countries. Misoprostol at the dose of 600 µg to 1000 µg was associated with higher percentages of side-effects, while sublingual route at the dose of 400 µg seems to be better in minimizing the adverse side-effects.
Authors and Affiliations
Joy Chidinma Agom
Keywords
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