EFFECTS OF ANTI ANXIETY DRUG MIDAZOLAM AS PRETREATMENT THERAPY FOR ANXIETY OF ZEBRA FISHES INDUCED BY THE EXPOSURE OF UNFAMILIAR ENVIRONMENT OF AQUATIC WHITE/BLACK MAZE
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
Objectves: The objective of our present research investigation was to evaluate the effectiveness of the aquatic white/black plus maze model toevaluate the efficacy of different treatment drugs on zebra fish behavior studies.Methods: Animals were divided into three groups each containing six animals. The first two groups were pretreated with lower and higher doses ofmidazolam and then they were exposed to unfamiliar environments of aquatic white/black plus maze. The last group of animals was only immersedinto the unknown familiar in the form of aquatic white/black plus maze without any pretreatment of the drugs.Results: The results illustrated that the pretreatment drugs certainly improved the behavior status of the animal in the form of releasing anxiety andstress, but the doses of different pretreatment have no significant effects on improvement of behavioral status.Conclusion: In conclusion, it can be described that this model is highly effective to find the proper drug for the treatment of anxiety but it is not soeffective to find the proper dose of treatment.Keywords: Midazolam, Zebra fish, White/black maze, Anti anxiety, Pretreatment therapy.
Authors and Affiliations
Surendra Vada, Divakar Goli, Anirbandeep Bose, Uday Raj Sharma
Keywords
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