Effects of Atorvastatin as Antioxidants in Diabetic associated Cardiovascular Complications
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 4
Abstract
Oxidative stress is pathogenetic hypotheses of vascular complication in diabetes by impaired endothelial dysfunction (ED) and antioxidant status. The endothelium is complex organ essential for controlling vascular functions. Vascular ED leads to pathogenesis of diabetic associated cardiovascular complications. The aim of present study was to evaluate the role of Atorvastatin in diabetic cardiovascular complications. Atorvastatin, HMG-CoA reductase inhibitors used as lipid lowering began to emerge; such pleiotropic effects include improvement of ED, increased Nitric oxide (NO) bioavailability, antioxidant, anti-inflammatory activities. Hence to evaluate the effect of Atorvastatin in diabetic vascular complications, we studied the effect of Atorvastatin on acetylcholine responses in thoracic aorta isolated from streptozotocin (60 mg/ kg i.p.) induced 8 weeks diabetic rats. Acetylcholine induced relaxation response was significantly decreased in aortic strips from diabetic with compared to control rats. Lipidperoxidation was significantly increased while Superoxide dismutase (SOD) and Catalase activity were significantly decreased in aorta of diabetic rats with compared to control rats. The systolic, diastolic and mean arterial pressure (MAP) was significantly increased in diabetic rats with compared to control rats. Diabetic rats treated with Atorvastain (20 & 40 mg/kg/day) for 8 weeks selectively restored ED relaxation response of acetylcholine to near the reactivity observed in vessels from control rats. The enhanced lipidperoxidation, systolic, diastolic and MAP and reduced SOD and Catalase activity were significantly restored to control values following Atorvastain treatment. From results we infer that Atorvastain improves diabetes-induced ED by reducing oxidative stress and blood pressure, increasing relaxation responses of acetylcholine. So it could be an ideal intervention in therapy of diabetic associated cardiovascular complications.
Authors and Affiliations
Patel Timir B , Dr. L. D. Patel , Patel Tejas B , Makwana Sunil H , Dr. S. P. Adeshara
Keywords
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