Optimization of Eudragit RS Microspheres for controlled release of Theophylline using Response Surface Methodology
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 10
Abstract
The present study reports on the production of theophylline loaded Eudragit RS microspheres for controlled release. The microspheres were prepared by the emulsion solvent evaporation technique using Eudragit RS as the polymer. A three-factor, three-level design of experiment (DOE) with response surface methodology (RSM) was run to evaluate the main and interaction effect of several independent formulation variables that included theophylline concentration (X1), stirring rate (X2) span 80 concentration w/w (X3). The dependent variables included encapsulation efficiency (Y1) and cumulative percent release at 6hrs (Y2). A desirability function was used to maximize encapsulation efficiency and to obtain controlled release formula.The drug concentration had a positive effect on the encapsulation efficiency and a negative effect on cumulative recent release, stirring rate and span concentration had a positive effect on the cumulative recent release and a negative effect on encapsulation efficiency. Drug-loaded microspheres were spherical in shape and had a smooth surface with encapsulation efficiency ranging between 26.48 – 51.41%. Cumulative percent release were 39 - 69% for the 6hrs under most of the operating parameters studied.
Authors and Affiliations
Hanan M. El-Nahas
Keywords
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