Optimization of Eudragit RS Microspheres for controlled release of Theophylline using Response Surface Methodology
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 10
Abstract
The present study reports on the production of theophylline loaded Eudragit RS microspheres for controlled release. The microspheres were prepared by the emulsion solvent evaporation technique using Eudragit RS as the polymer. A three-factor, three-level design of experiment (DOE) with response surface methodology (RSM) was run to evaluate the main and interaction effect of several independent formulation variables that included theophylline concentration (X1), stirring rate (X2) span 80 concentration w/w (X3). The dependent variables included encapsulation efficiency (Y1) and cumulative percent release at 6hrs (Y2). A desirability function was used to maximize encapsulation efficiency and to obtain controlled release formula.The drug concentration had a positive effect on the encapsulation efficiency and a negative effect on cumulative recent release, stirring rate and span concentration had a positive effect on the cumulative recent release and a negative effect on encapsulation efficiency. Drug-loaded microspheres were spherical in shape and had a smooth surface with encapsulation efficiency ranging between 26.48 – 51.41%. Cumulative percent release were 39 - 69% for the 6hrs under most of the operating parameters studied.
Authors and Affiliations
Hanan M. El-Nahas
Keywords
Related Articles
- EP ID EP107953
- DOI -
- Views 98
- Downloads 0
ormulation and Evaluation of Clarithromycin Extended Release Tablets
The Present study to investigate the formulation development of orally administrable Clarithromycin delayed release tablet. Clarithromycin tablet was designed for the delaying the release to prolong the durati...
Synthesis, Characterization and Fluorescence study of Certain Cinnamamide Derivatives and α, β unsaturated acids
A series of Cinnamamide were prepared by condensation of appropriate malonic acid derivatives with several aldehydes in presence of condensing agent and in its absence α, β Unsaturated acids were synthesized. The synthes...
[b][/b]Evaluation of antimicrobial activity and phytochemical screening of Gelidium acerosa
Seaweeds has become a recognized potential natural product in pharmaceutical industries. The Gelidium acerosa contain large amount of valuable phytochemicals like sapononins, flavinoids and alkaloids etc...
Comparative study on the suitability of different substrates for Tannin Acyl Hydrolase production using Aspergillus oryzae
An extracellular tannase produced by the fungus Aspergillus oryzae in solid state fermentation using various agricultural by-products. Among different substrates used the maximum activity of 14.40 U/g/min was...
Invitro Anti helmentic Activity of aqueous and alcoholic extracts of Aerva lanata Seeds and leaves
The antiparasitic activity of the seed and leaf extracts of Aerva lanata (Amaranthaceae) were tested against a tapeworm and an earthworm, particularly ethanolic extract showing to be better against tapeworms and earthwor...