Effects of daglipzin on renal function and miR-21-5p and miR-423-5p levels in patients with diabetic nephropathy
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 8
Abstract
Objective</b>To analyze the effects of dapagliflozin on blood glucose levels, renal function, and the levels of miR-21-5p and miR-423-5p in patients with diabetic nephropathy. Methods A total of 98 patients with diabetic nephropathy admitted in The Second People's Hospital of Hefei from February 2022 to October 2023 were selected and divided into the control group (n=49) and the observation group (n=49) according to the random number table method. The control group was treated with metformin, and the observation group was treated with a combination of metformin and dapagliflozin. Blood glucose levels, renal function, expression levels of miR-21-5p, miR-423-5p and serum proinflammatory factors before and after treatment were compared between the two groups, and the incidence of adverse reactions was recorded. Results The levels of fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and serum creatinine (Scr), blood urea nitrogen (BUN), cystatin C (Cys-C) in both groups decreased after 3 months of treatment, and the above indexes in the observation group were lower than those in the control group (P<0.05). Similarly, levels of miR-21-5p, miR-423-5p, C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were significantly lower in the observation group compared to the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group (12.24% vs6.12%, P>0.05). Conclusion Daglipzin can help improve the blood sugar level and renal function of patients with diabetes nephropathy, reduce the expression of miR-21-5p, miR-423-5p and the level of serum proinflammatory factors, with good safety.
Authors and Affiliations
MA Tingting*, LIU Li, XU Ping, SHAN Liang（*Department of Nephrology, The Second People's Hospital of Hefei, Hefei, Anhui 230000， China）
Keywords
Related Articles
- EP ID EP743099
- DOI 10.13429/j.cnki.cjcr.2024.08.016
- Views 27
- Downloads 0
Comparative study of three ways for treating the appendiceal stump after acute appendicitis under laparoscopy
Objective To investigate the advantages and disadvantages of purse-string suture, Hem-o-lok clip and double thread ligation in the treatment of appendiceal stump. Methods A retrospective study was conducted on 237 acute...
Research progress of fibroblast growth factor receptor in gastric cancer
The incidence and mortality of gastric cancer are in the forefront of the tumor, and the prognosis is poor, especially in the middle and advanced stage. Even with comprehensive treatment, the 5- year survival is very lo...
Correlation between low density lipoprotein subtype and acute cerebral infarction in patients with type 2 diabetes mellitus
Objective To investigate the relationship between low density lipoprotein (LDL) subtypes and acute cerebral infarction (ACI) in type 2 diabetes mellitus (T2DM). Methods A retrospective analysis was conducted on 292 T2DM...
Research progress of short-chain fatty acids and the relationship between immune regulation and sepsis
Short-chain fatty acids are saturated fatty acids produced by specific intestinal flora, which have various functions such as maintaining intestinal homeostasis and participating in immune regulation. In recent years, th...
Moxibustion at Neiguan acupoint in the prevention of myocardial damage caused by chemotherapy in breast cancer
Objective To investigate the effect of moxibustion on Neiguan acupoint in preventing myocardial damage caused by anthracycline-based chemotherapy in breast cancer patients, and to explore the feasibility of moxibustion o...