Effects of low doses of intracerebroventricular 6-OHDA on the levels of monoaminergic neurotransmitters in rat brain structures.
Journal Title: Pharmacological Reports - Year 2010, Vol 62, Issue 6
Abstract
The objective of this study was to determine the degree and specificity of noradrenergic lesions in different areas of the rat brain after intracerebroventricular administration of low doses of 6-hydroxydopamine (6-OHDA) into both lateral ventricles. Our interest focused on the induction of an effective hypothalamic lesion. The results suggest that small doses of 6-OHDA (25 or 50 μg per ventricle) could effectively damage the noradrenergic system in the hypothalamus without significant interfering with the dopamine level and with only a modest reduction in the serotonin concentration.
Authors and Affiliations
Anna Sadakierska-Chudy, Krystyna Gołembiowska, Władysława Daniel
Keywords
Related Articles
- EP ID EP139680
- DOI -
- Views 116
- Downloads 0
Characterization of acute adverse-effect profiles of selected antiepileptic drugs in the grip-strength test in mice.
The aim of this study was to assess the acute adverse effects (neurotoxic) of several antiepileptic drugs (clonazepam, lamotrigine, oxcarbazepine, phenytoin, phenobarbital and topiramate) by measuring skeletal muscular s...
Antithrombotic effect of captopril and enalapril in old rats.
In the present study, we have shown considerably accelerated thrombosis in old rats in comparison with adult rats, which may be related to the impaired hemostatic balance in these animals. In old rats, captopril and enal...
Nitrate tolerance as a model of vascular dysfunction: Roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress.
Organic nitrates are a group of very effective anti-ischemic drugs. They are used for the treatment of patients with stable angina, acute myocardial infarction and chronic congestive heart failure. A major therapeutic li...
Prenatal tolerability of acetaminophen and other over-the-counter non-selective cyclooxygenase inhibitors.
Over-the-counter cyclooxygenase inhibitors are used to relief fever and various types of acute pain like headache, toothache, earache, sore throat, as well as postoperative and menstrual ones. They are also major ingredi...
Effect of prior stress on interleukin-1β and HPA axis responses to acute stress.
Interleukin-1β (IL-1β) level is modulated during multiple stress reactions both in brain structures involved in hypothalamic-pituitary-adrenal (HPA) axis regulation and peripheral systems. Multiple distinct stressors ind...