Effects of Rosiglitazone on Metabolic Parameters and Adiponectin Levels in Fructose-Fed Rats
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2009, Vol 2, Issue 1
Abstract
Aim. To investigate the effect of the peroxisome proliferators-activator receptor gamma agonist, rosiglitazone, on metabolic parameters and adiponectin levels in an animal model of the metabolic syndrome. Material and methods. Metabolic syndrome was induced in 32 male Wistar rats by adding a fructose in drinking water for 12 weeks. During the last 4 weeks, 16 rats were treated with rosiglitazone (5 mg/kg/day), while the remaining 16 did not receive any medication (fructose group). Another control group consumed standard rat chow and water for 12 weeks. Results. Chronic fructose administration induced a significant increase in systolic blood pressure (SBP), body weight, serum triglycerides (TG), free fatty acids (FFA), insulin, glucose AUC0-120 (during oral glucose tolerance test) and decreased serum high density lipoprotein (HDL) cholesterol and adiponectin concentrations compared with the control group. Treatment with rosiglitazone over the final 4 weeks reversed these effects and significantly reduced SBP, TG, FFA, insulin concentrations and glucose AUC0-120 compared with the fructose group. In addition, rosiglitazone increased serum levels of adiponectin twofold from 3.44 ± 0.46 to 7.03 ± 1.30 μg/ ml. Conclusion. This study indicates that rosiglitazone treatment improves the components of the metabolic syndrome, which is accompanied with an increase in adiponectin concentrations.
Authors and Affiliations
Emilija Atanasovska| Institute of Preclinical and Clinical Pharmacology with Toxicology, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Krume Jakovski| Institute of Preclinical and Clinical Pharmacology with Toxicology, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Elena Kostova| Institute of Preclinical and Clinical Pharmacology with Toxicology, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Aleksandar Petlichkovski| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Chedo Dimitrovski| Endocrinology and Metabolic Disorders Clinic, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Iskra Bitovska| Endocrinology and Metabolic Disorders Clinic, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Igor Kikerkov| Institute of Preclinical and Clinical Pharmacology with Toxicology, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Ognen Petrovski| Institute of Preclinical and Clinical Pharmacology with Toxicology, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Nikola Labachevski| Institute of Preclinical and Clinical Pharmacology with Toxicology, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia
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- EP ID EP8652
- DOI 10.3889/MJMS.1857-5773.2009.0037
- Views 308
- Downloads 18
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