Effects of sodium fluoride on bone metabolism and structural changes of the mandible in ovariectomized rats
Journal Title: Problemy Nauk Stosowanych - Year 2018, Vol 8, Issue
Abstract
Introduction and aim: The role of fluorides in caries prevention is widely known, however, due to a large number of factors affecting the metabolism of bone tissue (e.g. estrogens), the evaluation of the effect of these compounds on the masticatory system requires comprehensive studies. The aim of the study was to examine the effect of fluorides on the chosen biochemical markers of bone remodelling, on the bone mass and structural changes in the lower jaw (mandible) of castrated rats, after six-week exposure to sodium fluoride in different doses. Material and methods: The experiment was conducted on an animal model using female Wistar rats divided into four groups: a control group and three research groups (ovariectomized and exposed to fluoride compounds in different doses in the drinking water). In order to evaluate the effect of estrogens shortage induced by double-sided ovariectomy and to analyze the fluorides influence on bone metabolism and structural changes of the mandible, tests of bone tissue metabolism markers, bone mineral content in the mandible, height of a molar tooth, height of alveolar appendix and index of rats' alveolar appendices heights were performed. Results: Ovariectomy procedure led to the appearance of higher concentrations of bone tissue resorption markers and lower mineral weight of mandible, but did not exert a considerable impact on mineral weight index in animals receiving fluorides. There was no statisti-cal difference in the heights of molar teeth between all experimental groups. Conclusion: Eestrogens shortage, due to ovariectomy, reduces mineral weight of lower jaw bones and mineral weight index, and the fluoride supply prevents the loss of minerals from an osseous tissue.
Authors and Affiliations
Andrzej Bohatyrewicz, Małgorzata Wiechowska, Anna Machoy-Mokrzyńska, Alina Jurewicz, Katarzyna Leźnicka, Maciej Karaczun, Elżbieta Weyna
Keywords
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