Effects of vitamins E and C in reduction of preeclampsia blood pressure incidence in primigravids
Journal Title: مجله دانشگاه علوم پزشکی شهرکرد - Year 2007, Vol 9, Issue 1
Abstract
Background and aim: The preeclapsia causes about 5-10 of pregnancies to be complicated and leads to increasing maternal morbidity and mortality rate in both mother and fetus. One of proposed preventions is using of antioxidants during pregnancy. Therefore, the aim of this study was to investigate the effects of vitamins E and C on the pregnancy-related blood pressure as the major sign of the preeclapsia. Methods: In this clinical trial study, 150 primigravids, aged 20-35, gestational age 20 weeks, singleton, negative family history of preeclampsia, chronic hypertension or other organic disease, with normal BMI, nonsmokers, moderate socioeconomic level and without molar pregnancy and polyhydramnious, are divided into two equal groups of case and control. The case group received 500 mg vitamin C and 400 IU vitamin E every day. The control group received no vitamin. Using a questionnaire, the data were obtained and analyzed using t, paired t and Fisher exact statistical tests. Results: The preeclampsia rates were 2 (2/6%) and 11 (14/7%) in the case and control groups, respectively (p0.05). In the case group, the mean of pressure was 60.2±8.3 mmHg before diastolic and 65.5±3.8 at the end of pregnancy and after the intervention. In the control group, this parameter was 59.6±20 and achieved to 72.2±16 at the end of the pregnancy (p
Authors and Affiliations
afsaneh Taghriri, azar Danesh
Keywords
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