Efficacy and safety of oral fluconazole vs topical antifungal imidazoles in tinea corporis: A comparative therapeutic trial
Journal Title: Medpulse International Journal of Pharmacology - Year 2018, Vol 6, Issue 1
Abstract
Background:Dermatophytes are the most common causes of superficial fungal infections worldwide. All dermatophytosis of glabrous skin except the palms, soles and groin are categorized under tinea corporis. Dermatophytic infections may be treated with both topical and systemic therapies. The present study aims to assess the efficacy and safety of oral fluconazole in comparison to topical antifungal miconazole nitrate and ketoconazole against tinea corporis.Methodology:This study is an open labelled comparative trial. About 60 patients (n =60) with dermatophytosis attending outpatient clinic of dermatology department of Government Medical College, Kozhikode, Kerala, India, were selected randomly. The diagnosis and prognosis was done by clinical and microscopic examination by mounting skin scrapings in 10% KOH solution. The comparison of efficacy was done by chi-square test. The cure rate in each group was expressed as percentage.P value of <0.05 was considered significant and <0.01 as highly significant.Results: The cure rate in tinea corporis with oral fluconazole therapy at the dose of 150 mg weekly for 3 weeks was 100 %. The cure rate observed with miconazole and ketoconazole were 60% and 53% respectively.Fluconazole treatment does not resulted in serious adverse effects and safer for short term therapy of tinea corporis.Conclusion: Oral fluconazole is more effective than topical antifungal agents like miconazole nitrate and ketoconazole for the treatment of tinea corporis.
Authors and Affiliations
Mohamed Salim Valiyakathoy, Soopy Kayanaduth, Roopashree Gopinath
Keywords
Related Articles
- EP ID EP360067
- DOI -
- Views 103
- Downloads 0
A study of effectiveness of statins in patients of rheumatoid arthritis at tertiary health care centre
Background:Rheumatoid arthritis is chronic inflammatory condition involving multiple systems. Statims have anti-inflammatory properties like regulating leukocyte-endothelial cell adhesion, reducing nitric oxide (NO) prod...
Effect ofaddition of trimetazidine on LV function in patients with LV systolic dysfunction receiving optimal medical therapy in comparison with patients receiving only optimal medical therapy in a tertiary care centre
Background: Left ventricular dysfunction (LVD) can lead to congestive cardiac failure.LVD was traditionally managed by antiplatelets, diuretics, antihypertensives and statins. However studies have shown that addition of...
Patterns of prescription in a psychiatry out-patient department in a tertiary teaching hospital
Background: There is constantly increasing prevalence of psychiatric morbidity in Jammu and Kashmir State. Study of prescription pattern helps us to monitor, evaluate and if necessary suggest modifications in prescribing...
Socio-demographic and clinical profile and utilization pattern of antipsychotic drugs among psychiatric out-patients
Background: Drug prescribing pattern varies in different geographical areas as it is influenced by patient characteristics, type of disease prevalent, cultural and environmental factors, available drugs and prescribing h...
A Study to compare antiasthmatic activity of Cilnidipine and Amlodipine with Salbutamol
Background: Cilinidipine can act on the N-type calcium-channel that existing sympathetic nerve end besides acting on L-type calcium-channel that similar to most of the calcium antagonists. Due to its N-type calcium-chann...