A Study to compare antiasthmatic activity of Cilnidipine and Amlodipine with Salbutamol
Journal Title: Medpulse International Journal of Pharmacology - Year 2017, Vol 4, Issue 1
Abstract
Background: Cilinidipine can act on the N-type calcium-channel that existing sympathetic nerve end besides acting on L-type calcium-channel that similar to most of the calcium antagonists. Due to its N-type calcium-channel blocking properties, it has more advantages compared to conventional calcium-channel blockers. It has lower incidence of Pedal edema, one of the major adverse effects of other calcium channel blockers Methodology: Guinea pigs were divided in to four groups with six animals in each. They were treated with respective drugs for a period of 5 days. On 4th day they were housed in aerosol chamber for acclimatization. On 5th day, 2 hours after drug administration each guinea pig was exposed to aerosols of histamine in the histamine chamber. PCD time was noted. Just before onset of convulsion animals were shifted to fresh air and allowed to recover. The subsequent week same process of drug administration was followed. Results: The test groups also showed a significant and increase in the mean PCD time when compared to control group of animals. Cilnidipine had an increase of about 73.1seconds and 73.33 seconds in histamine induced bronchoconstriction method and acetylcholine induced bronchoconstriction method respectively. Amlodipine had an increase of about 58.5 seconds and 63 seconds in histamine induced bronchoconstriction method and acetylcholine induced bronchoconstriction method respectively. Conclusion: They will be of significant value in patients who are hypertensive and also asthmatics
Authors and Affiliations
M D Sibgatullah, Shruthi S L
Keywords
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