Efficacy of Oral Zinc Acetate in Reducing Hyperbilirubinemia in Full-Term and Near-Term High Risk Neonates
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Objective: To determine the efficacy of oral zinc supplementation in reducing incidence of hyperbilirubinemia and level of serum total bilirubin (STB) during the first week of life in full-term and near-term high risk neonates in comparison with placebo. Method: We conducted a randomized double-blind placebo-controlled trial on 100 neonates born at ≥35 weeks of gestation with STB ≥5 mg/dl at 24 ± 6 hours of age. They were administered either 10 mg zinc acetate syrup (zinc group) or placebo (control group) in twice daily doses till day 7 of life. Incidence of hyperbilirubinemia (STB ≥15 mg/dl) anytime between day 2 to 7 of life and mean STB levels on day 7 of age were compared between the two groups. Results: Incidence of hyperbilirubinemia was significantly lower in the zinc group (8%) as compared to placebo group (26%); p= 0.033. Mean STB level on day 7 of life was significantly lower in the zinc group (7.828±3.36 mg/dl) as compared to placebo group (9.474±3.1mg/dl); p= 0.017. No significant adverse effects related to oral zinc administration were noted. Conclusion: Oral zinc in a dose of 10 mg/day reduces the incidence of hyperbilirubinemia and mean STB levels in the first week of life in at-risk full-term and near-term neonates.
Authors and Affiliations
Dr. Karnika Agrawal, Dr. Surendra Kumar, Dr. R. S. Sethi3
Keywords
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- EP ID EP362993
- DOI 10.9790/0853-1702092731
- Views 68
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