Efficacy of Zonisamide – Levetiracetam Comedication in Nine Adult Patients with Difficult to Treat Epilepsy and Intellectual Disability (A Case Series Report)
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2012, Vol 5, Issue 1
Abstract
Aim: Few studies have concerned anticonvulsive combination therapies in epilepsies resistant to established antiepileptic drugs in monotherapy. We sought to delineate the effects of zonisamide – levetiracetam comedication (ZNS+LEV) in adults with intellectual disabilities (ID). Material and Methods: Nine adult patients with drug resistant epilepsies and ID were treated in a routine outpatient setting with LEV or ZNS in combination with other anticonvulsants first and in a combination of both of them (ZNS+LEV) thereafter. Seizure frequency and behavioural effects were recorded in patients treated who approved to benefit from the combination of both substances but not when treated with only either of them. Results: The longitudinal follow up of individual cases of patients with difficult to treat epilepsies and intellectual disabilitiy (ID) suggests that the combination of ZNS and LEV may be an effective and well tolerated option, even if LEV or ZNS alone or in either other combinations had failed to reduce seizure frequency. Conclusions: These findings may not be generalized but request to perform further controlled studies on the efficacy and tolerability of the anticonvulsive therapy of ZNS in combination with LEV.
Authors and Affiliations
Peter Martin | Séguin Clinic for Persons with Severe Intellectual Disability, Epilepsy Centre Kork, Landstr 1, D-77694 Kehl-Kork, Germany, Jörg Fahrbach| Séguin Clinic for Persons with Severe Intellectual Disability, Epilepsy Centre Kork, Landstr 1, D-77694 Kehl-Kork, Germany
Keywords
Related Articles
- EP ID EP8851
- DOI 10.3889/MJMS.1857-5773.2011.0211
- Views 328
- Downloads 15
Bgl II Polymorhism of the α2β1 Integrin Gene in Macedonian Population
Background. Glycoprotein (GP) Ia/IIa or α2β1 integrin is a platelet receptor for collagen and it mediates platelet adhesion to vascular subendothelium and is involved in thromb formation. Genetic polymorphism of α2Î...
Antidiabetic Activities of Foeniculum Vulgare Mill. Essential Oil in Streptozotocin-Induced Diabetic Rats
Background: Foeniculum vulgare Mill (F. Apiaceae) is an ancient common herb and spice known to the ancient Egyptians and Greeks, traditionally used as a carminative, a weak diuretic and lactation stimulant. Aim: To ev...
Multidiciplinary Treatment of a Haemophilic Person with Total Hip Replacement Surgery- A Case Report
Background: Treatment of hemophilic arthropathy may be conservative and operative. Conservative therapy includes medications and physiotherapy, and surgery includes synovectomy, tendon release, capsulotomy, osteotomy a...
Modern Approach to the Identification and Elimination of Periodontal Infection
In global terms, periodontitis is the leading cause of tooth loss, and causes serious aesthetic and functional problems. There are numerous scientific evidence that power periopathogenic microorganisms may have influen...
Impact of Balanced Caloric Diet and Physical Activity on Body Composition and Fat Distribution of Obese Egyptian Adolescent Girls
Objective. The aim of this study was to evaluate the effects of 6 months of balanced caloric moderately deficit diet program combined with individualized moderate Physical exercise on the body weight, body composition...