Electrolytes Alterations in Some Organs due to Lead Exposure
Journal Title: Advances in Clinical Toxicology - Year 2019, Vol 4, Issue 1
Abstract
Background: Lead is one of the metals whose toxicological effect in humans and animals is of clinical concerned. Once it is absorbed, it is distributed via the blood to various tissues and organs where they are stored. Electrolytes played significant role in metabolic and physiological processes taken in the body. We investigated some electrolytes distribution in the blood, liver, kidney, spleen and brain of male Albino rats exposed to different concentrations of lead as lead acetate. Methods: A total of sixteen male Wistar rats were used for the experiment. They were randomly divided into four groups (A-D) of four animals per group and were treated with lead acetate orally as the source of lead exposure for a period of four, eight and twelve weeks. Results: The results showed a significant increase in blood lead concentration and decrease in plasma sodium, potassium, and calcium and magnesium concentrations. The electrolytes concentrations in various organs studied showed different patterns of variations which were dose and time dependent. Conclusions: It can be concluded that exposure to lead could result in perturbation of electrolytes in blood and different organs thus interfering with electrolytes metabolism resulting in deterioration of cellular functions.
Authors and Affiliations
Okediran B Samuel*, Sanusi F and Suleiman K Yusuf
Obesity, Diets and Pollution
In the past decades, the problem of obesity has grown exponentially, particularly in the industrialised countries, so that in the next few years the statistical predictions of the World Health Organisation (WHO) estim...
Toxicological Implications of Hexavalent Chromium in Humans
Heavy metals are quite important as far as industrial production is concerned. This may be attributed to several characteristic properties of the metals which include high strength, durability, high melting and/or boili...
The Menace of Lead Poisoning in Pakistan
Environmental pollution has been increased many times due to increase in population, industrialization and urbanization; in some places, it becomes toxic to living organisms. Among the pollutants, heavy metals pose th...
Electrolytes Alterations in Some Organs due to Lead Exposure
Background: Lead is one of the metals whose toxicological effect in humans and animals is of clinical concerned. Once it is absorbed, it is distributed via the blood to various tissues and organs where they are stored....
Epidemiology of Pesticides in Developing Countries
Chemical pesticides are group of substances of different classes according to their target species (Eg. herbicides and insecticides), that are created for eradication and control of pests. A global trend of transition f...