Elevated concentrations of plasma homocysteine in coronary artery disease patients with normal folate level.
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 2
Abstract
Hyperhomocysteinemia is becoming a growing concern as a risk factor in patients suffering from coronary artery disease. The purpose of our study was to evaluate the existence of hyperhomocysteinemia with folate levels along with conventional risk factors. A total of 80 cases (50 patients and 30 controls) were studied. Abnormal 12 lead echocardiogram (ECG) served as criteria for inclusion. Out of 50 patients 42 were men and 8 were women. Controls were age and sex matched. Total plasma homocysteine in patients was 211.9 (p<0.0001) and controls 11.70.7. Folate levels were 8.21.2 and 7.40.8 (p<0.323) in patients and controls respectively. All the other conventional risk factors were found not statistically significant when compared to homocysteine. Despite normal folate levels elevated homocysteine levels exist in patients suffering from coronary artery disease. Since homocysteine is a modifiable risk factor, testing for homocysteine must be included in risk assessment and diagnosis of coronary artery disease.
Authors and Affiliations
Bejoy Baby , Saravanan G, Chinnaswamy P
Keywords
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