ELEVATION OF SERUM C-REACTIVE PROTEIN AND S100 PROTEINS FOR SYSTEMIC INFLAMMATION IN AUTISTIC CHILDREN
Journal Title: Journal of Special Education and Rehabilitation - Year 2005, Vol 6, Issue 3
Abstract
The pathogenesis of autism, a neurological disorder severely affecting young children, may involve inflammation and autoimmunity. In this report, the distribution of acute-phase C-reactive protein (CRP) and S100 proteins was examined in normal and autistic children. Their serum levels were measured by enzyme-linked immunosorbent assay (ELISA). Autistic children were found to have significantly higher than normal levels of CRP (p=0.005) and S100 proteins (p=0.03). The existence of elevated levels of CRP and S100 proteins in autistic children is an excellent sign of systemic inflammation that may contribute to the neuropathology of this brain disorder.
Authors and Affiliations
Vijendra K. SINGH| Department of Biology, Utah State University, Logan, USA
Keywords
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