Endometrial receptivity forming elements
Journal Title: Ginekologia i Położnictwo medical project - Year 2015, Vol 4, Issue 38
Abstract
This paper discusses significant elements that make up the decidualization of the endometrium which renders this tissue capable of embryo implantation, i.e. makes it receptive. Subsequently, angiogenesis, penetration of the endometrium by macrophages, immune polarization and the problem or maternal immune tolerance to the embryo are discussed. A significant element for effective implantation is the site where the apical layer of the decidua communicates with the outer surfaces of the embryo. This communication is facilitated or prevented by adhesion molecules present in the endometrium. Leukemia inhibitory factor (LIF) and its receptor are particularly emphasized. Other markers mentioned in the paper are: mucin (MUC1), glycodelin A, integrins, L-selectin, interleukins (IL-1 and IL-6), E-cadherin and cyclin. Finally, a search for genetic markers of endometrial receptivity and the role of HOXA-10 and HOXA11 genes are presented.
Authors and Affiliations
Anna Bednarska-Czerwińska, Dariusz Mercik, Michał Czerwiński
Keywords
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