Endothelial Progenitor Cells in Diabetic Foot Syndrome
Journal Title: Advances in Clinical and Experimental Medicine - Year 2012, Vol 21, Issue 2
Abstract
In the late 20th century endothelial progenitor cells (EPCs) were discovered and identified as cells capable of differentiating into endothelial cells. Antigens characteristic of endothelial cells and hematopoietic cells are located on their surface. EPCs can proliferate, adhere, migrate and have the specific ability to form vascular structure, and they have a wide range of roles: They participate in maintaining hemostasis, and play an important part in the processes of vasculogenesis and angiogenesis. They are sources of angiogenic factors, especially vascular endothelial growth factor (VEGF). EPCs exist in bone marrow, from which they are recruited into circulation in response to specific stimuli. Tissue ischemia is thought to be the strongest inductor of EPC mobilization. Local ischemia accompanies many pathological states, including diabetic foot syndrome (DFS). Impaired angiogenesis – in which EPCs participate – is typical of DFS. An analysis of the available literature indicates that in diabetic patients the number of EPCs declines and their functioning is impaired. Endothelial progenitor cells are crucial to vasculogenesis and angiogenesis during ischemic neovascularization. The pathomechanisms underlying impaired angiogenesis in patients with DFS is complicated, but the discovery of EPCs has shed new light on the pathogenesis of many diseases, including diabetes foot syndrome.
Authors and Affiliations
Ewelina Drela, Katarzyna Stankowska, Arleta Kulwas, Danuta Rość
Keywords
Related Articles
- EP ID EP161123
- DOI -
- Views 109
- Downloads 0
Ultrasonographic Assessment of the Thyroid Gland Structure in Inflammatory Bowel Disease Patients
[b]Background. [/b]The etiopathogenesis of inflammatory bowel disease (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), is still not fully elucidated and seems to be multifactorial. It has been sugges...
The Effect of Exhaustive Exercise on Oxidative Stress Generation and Antioxidant Defense in Guinea Pigs
[b]Abstract [/b] [b]Background.[/b] Exercise induces a multitude of physiological and biochemical changes in blood that can affect its redox status. Exercise causes an increase in oxygen consumption by the whole body an...
Neuroprostheses for Increasing Disabled Patients’ Mobility and Control
Neuroprostheses are electronic devices using electrophysiological signals to stimulate muscles, electronic/mechanical devices such as substitutes for limbs or parts of limbs, or computers. The development of neuroprosthe...
Assessment of Quality of Life of Parents of Children with Osteogenesis Imperfecta
[b]Objectives.[/b] The aim of the work was an objective assessment of the quality of life of parents of children with osteogenesis imperfecta (OI) and of its determinant factors. [b]Material and Methods.[/b] The survey...
Quantitative Diagnosis of Early-Stage Liver Cirrhosis with Contrast-Enhanced Ultrasound – A Clinical Study
[b]Objectives.[/b] To investigate the quantitative diagnosis value of contrast-enhanced ultrasound (CEUS) for early-stage liver cirrhosis. [b]Material and Methods.[/b] A total of 15 healthy subjects and 15 patients wit...