Energetic capabilities of peripheral blood cells and their correction by autoplasma, enriched with platelets in patients with acne
Journal Title: Український журнал дерматології, венерології, косметології - Year 2018, Vol 0, Issue 1
Abstract
Objective — to assess the energy potential of leukocytes and peripheral blood platelets by studying the content of intracellular glycogen and determining the therapeutic efficacy of plateletrich autoplasma in patients with acne. Materials and methods. We observed 31 patients with an average severity of acne (18 women and 13 men) aged 16 to 39 years. The duration of the pathological process ranged from 6 months up to 18 years. The comparison group was formed by 15 healthy individuals, comparable in sex and age. All patients were previously treated by traditional means both independently and in specialized medical institutions, however, the effect was temporary or absent. A study was made of the glycogen content in neutrophils, monocytes, and peripheral blood platelets by setting up a PAS reaction, the results of which were assessed by determining the average cytochemical coefficient (CSC). The statistical processing of the data was carried out using a computer program Microsoft Excel. Results and discussion. It has been established that in patients with acne, the glycogen content in neutrophils decreases to SCC = 1.72 ± 0.12 (in control CSC = 2.31 ± 0.08, p < 0.05). This indicates change in the energy potential of individual leukocyte subpopulations. In the thrombocytes, the glycogen content remained within the limits of physiological fluctuationsSCC = 1.39 ± 0.08 (in the control SCC = 1.43 ± 0.09, p > 0.05), however, the number of cells with different saturation of the metabolite was redistributed. It has been shown that the effectiveness of treatment of such patients is improved by using autoplasma enriched with platelets as an adjuvant. Conclusions. With acne, there is a redistribution of the energy potential of neutrophils and monocytes of peripheral blood. The content of glycogen in neutrophils and monocytes of peripheral blood can serve as one of the criteria for the effectiveness of the prescribed therapy. The use of acupuncture enriched with platelets in acne can improve the effectiveness of treatment due to its modulating effect on the metabolic activity of leukocytes and platelets of peripheral blood.
Authors and Affiliations
O. S. Swyryd-Dzyadykevich, J. A. Sylik, V. I. Stepanenko
Keywords
Related Articles
- EP ID EP280096
- DOI -
- Views 109
- Downloads 0
Investigation of the impact of Prostrolane Natural-B on the main pathogenetic links of inflammatory skin aging
Objective — to investigate the effectiveness of Prostrolane Natural-B (injectable biorevitalizant with filling effect) in patients with age-related skin changes based on the dynamics of immunohistochemical markers of inf...
Probiotics in dermatology
Probiotics are live microorganisms that, when administered in adequate amounts, may confer a health benefit on the host. We already know that their use is positively influencing key factors in the development of dermatol...
Experience of combined external therapy of atopic dermatitis complicated by secondary infection
Objective — to evaluate the efficacy and safety of the combined use of external preparations containing mometasonefuroate 0.1 %, mupirocin 2 % and naftifine hydrochloride 1 % in the treatment of atopic dermatitis complic...
Therapy of onychomycosis: problematic issues and practical guidelines
Changes in nail plates for various diseases of fungal and non-fungal etiology are considered in the article. The expediency and specifics of using therapeutic varnish as a form of medication are shown, the advantages and...
Modern view on treatment of microsporia of children, taking into account the etiology, pathogenesis and features of clinical course of dermatosis
Objective — to analyze publications and summarize literature data on the optimization of the treatment of microsporia of children, taking into account the etiology, pathogenesis and features of the clinical course of der...