ESKAPE pathogens: Trends in antibiotic resistance pattern
Journal Title: Medpulse International Journal of Microbiology - Year 2018, Vol 7, Issue 3
Abstract
Background: Trend in resistance pattern of ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter, Pseudomonas aeruginosa, and Enterobacter/E.coli species) pathogens and their prevailing patterns in different types of infections was analyzed in this study. Methods: During a Three year study period (01 Jan 2013 to 31 Dec 2015), identification and susceptibility testing of ESKAPE pathogen were performed as per Clinical Laboratory Standards Institute (CLSI) guideline. Chi square for trend was used to analyze Trend in antibiotic resistance. Results: A reduction in Vancomycin resistant Enterococci (VRE) over the years from 6.0% in 2013 to 2.6% in 2014 and 1.2% in 2015 (p for trend=0.04) was observed during the reference period. Decline in trend was also noticed for Methicillin Resistant taphylococcus aureus (MRSA) (i.e.) 41.2%, 25% and 20% respectively from 2013-15 (p for trend >0.05) and for ESBL Klebsiella pneumoniae 89%, 74% and 51% ( p for trend is <0.0001).Regardless, a high prevalence of Multi drug resistant (MDR) Acinetobacter resistance was noted at baseline, but a less significant declining trend (52%, 71%, 25%) was followed over the years (p for trend >0.05). Klebsiella and Pseudomonas showed least proportion of resistance (2%) with a very good susceptibility profile among the ESKAPE pathogens. VRE, MRSA and MDR Acinetobacter were most commonly isolated from UTI (43%), wound swabs (50%) and Respiratory tract infections (76%) respectively. Conclusion: A declining trend in resistance pattern of ESKAPE organisms from the recent past was observed in this study. To facilitate better clinical decisions these findings should be emphasized in infection control training for health care providers.
Authors and Affiliations
N Shanmuga Vadivoo, B Usha
Keywords
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