Microbiological study of lower respiratory tract infection in a tertiary care government hospital, Nanded
Journal Title: Medpulse International Journal of Microbiology - Year 2018, Vol 7, Issue 3
Abstract
Background: Lower respiratory tract infections (LRTI) are among the most common infectious condition with potential for life threatening complications. The consequence of increased drug resistance among the pathogen causing LRTI's, are far reaching. Aims and objectives: 1.To determine the prevalence, etiology, and antimicrobial susceptibility pattern of identified bacterial pathogen among the patients with clinically suspected LRTI in our area. Methods and Material: A retrospective study was carried out over a period of six years among the total of 2421 hospitalized patients. Clinical observations were followed by conventional laboratory methods for diagnosis of aetiological agents and antibiotic sensitivity testing. Results: The prevalence of LRTI in present study was found as 32%. The commonest provisional diagnosis was moderate to severe pneumonia (40.5%) followed by bronchitis (15.5%) and pleural effusion (9.3%). Among all the samples, sputum displayed highest microbial isolation (68%) followed by pleural fluid 26%, and suction fluid /tip 13%. Ps. aeruginosa 283 (37%) was found to be the predominant organism followed by Klebsiella pneumoniae 190 (25%), E.coli 75 (9%). The predominant fungi observed was non albicans Candida (16)1.7%. Amikacin, ciprofloxacin, piperacillin- tazobactum, meropenum were found effective against GNB. Amikacin was found more effective drug than erythromycin, ciprofloxacin for GPC in our study. The multidrug resistant strains such as MRSA (1.6%), MRCONS (1.5%), and ESBL Klebsiella pneumoniae (1.4%), ESBL E.coli (0.8%) were also isolated. The multiple drug resistance (≥3 drugs) were seen among Ps aeruginosa (13.71%) followed by other enterobactericeae and Acinatobacter spp. (3%). Conclusions: In majority of patients, bacterial etiology was found predominant. Multiple drug resistance was observed among vast majority of bacterial pathogen. Although amikacin, ciprofloxacin, piperacillintazobactum, meropenum were found useful agents, the limited options were available for treatment.
Authors and Affiliations
Supriya M Emekar, S K Kandle
Keywords
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