Estrogen, progesterone receptors and breast cancer - an evaluative and correlative study
Journal Title: Medpulse International Journal of Pathology - Year 2017, Vol 1, Issue 2
Abstract
Background: Breast cancer is the second most common cause of cancer death worldwide. Estrogen and progesterone are the major hormones involved in regulation of breast tumor growth. The role of hormone receptors as a prognostic and therapeutic tool in breast cancer is now widely accepted. Aim and Objective: To evaluate the expression of estrogen and progesterone receptors in the breast carcinoma cases. To assess the correlation of estrogen and progesterone receptor with clinico-pathological parameters and to assess the value of Quick Score with reference to the histological grade of the tumor. Study design: Total 70 cases who underwent mastectomy for infiltrating duct carcinoma along with axillary lymph node dissection were taken into study. Male breast carcinoma cases were excluded from the study. Retrospective information like age of the patient, tumor size, histopathological diagnosis with Bloom Richardson grade of the tumor and lymph node metastases were recorded. Immunohistochemistry was performed using commercially available antibodies from NOVACASTRA for estrogen and progesterone receptor. Observation and Results: There was stastically significant inverse correlation between the grade of the tumor, tumor size, lymph node metastasis and the expression of estrogen and progesterone receptors. However no statistically significant correlation could be established between the age of the patient and expression of estrogen and progesterone receptors. Conclusion: Present study showed that with the increasing Grade of the tumor, size of the tumor, and positive lymph node metastasis the expression of estrogen and progesterone receptors decreases.
Authors and Affiliations
Tina Rai, Yogesh Patle, Garjesh S Rai
Keywords
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