A study of clinical profile of patients with mesenchymal tumour of gastrointestinal tract at SVIMS, Tirupati
Journal Title: Medpulse International Journal of Pathology - Year 2017, Vol 4, Issue 3
Abstract
Background: Although relatively rare, Gastrointestinal stromal tumors (GISTs), make up the largest subset of mesenchymal tumors of the gastrointestinal tract. GIST is known for its wide variability in biological behaviours and it is difficult to predict its malignant potential. The estimated annual incidence is 10-20 cases per million, of which only 20-30% are malignant. Aim and objectives: To study clinical profile of patients with mesenchymal tumour of gastrointestinal tract. Material and methods: It’s a retrospective, hospital record based study of twelve patients affected by GISTs between January 2009 and December 2011 for a period of 03 years. A GIST was defined as a mesenchymal tumor with immunohistochemical positivity for CD 117, the proto-oncogene protein of c-kit. Tumors were considered malignant if they had more than five mitoses per 50 high power fields. Results: In the present study, the age of patients varies between 51 years to 76 years with a mean of 65.3 years and standard deviation of 7.76 years( 65.3 ± 7.76 ). Females affected more than the males. The stomach (66.67%) being the commonest site involved by GISTs followed by small intestines (33.33%). Among the different presenting features, vague upper abdominal pain being the commonest feature encountered. Conclusions: It is important to distinguish GISTs from other mesenchymal tumors of the gastrointestinal tract because of differences in biologic behaviour and treatment strategies. The detection of GIST is based on imaging, endoscopy, histological and immunohistochemical examinations.
Authors and Affiliations
P Durga Prasad, P Vijay Kumar, Rashmi Patnaik, N Rukhmangadha
Keywords
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