Ethanolic Extract of Madhuhari Ameliorates Diabetes–Induced Oxidative Stress in Male Mice
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 5
Abstract
The primary aim of the present investigation was to evaluate the role of an antidiabetic polyherbal formulation, Madhuhari in the alloxan-induced oxidative stress in hepatic and renal tissues. Simultaneously DPPH (1,1-Diphenyl-2-picrylhydrazyl) and in vitro lipid peroxidation (LPO) assays were performed to ascertain the antioxidative potential of the test drug. For in vivo study 5 different doses (100, 200, 400, 800, and 1600 mg/kg) of ethanolic extract of Madhuhari were administered to male mice for 15 days. Alloxan was given on 11th day of drug treatment. On 16th day changes in above mentioned parameters were evaluated. Results revealed that, the lower doses of Madhuhari (100 and 200 mg/kg BW) nearly prevented all alloxan-induced adverse effects, suggesting its antihyperglycemic and antiperoxidative efficacy. However, higher doses were found to be less effective. Results of in vitro study also supported its free radical scavenging efficacy. It appears that the drug primarily acts through its antioxidative properties and pre-treatment with the test drug may ameliorate free radical induced diabetic complications.
Authors and Affiliations
Jyoti Agrawal*, Anand Kar
Keywords
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- EP ID EP385980
- DOI 10.9790/3008-110501108114
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