EUDRAGIT-BASED NANOSTRUCTURES: A POTENTIAL APPROACH FOR OCULAR DRUG DELIVERY
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2012, Vol 1, Issue 2
Abstract
Drug delivery in ocular therapeutics is a challenging problem and is a subject of interest to scientists working in the multidisciplinary areas pertaining to the eye. Most ocular diseases are treated by topical drug application in the form of solutions, suspensions and ointment. These conventional dosage forms suffer from the problems of poor ocular bioavailability, because of various anatomical and pathophysiological barriers prevailing in the eye. Various efforts in ocular drug delivery have been made to improve the bioavailability and to prolong the residence time of drugs applied topically onto the eye. The potential use of polymeric nanoparticles as drug carriers has led to the development of many different colloidal delivery vehicles. Indeed, the association of an active molecule to a nanocarrier allows the molecule to intimately interact with specific ocular structures, to overcome ocular barriers and to prolong its residence in the target tissue. This review discusses the physiochemical characterization, fabrication techniques, therapeutic significances, patented technology of Eudragit based nanoparticles and future possibility in the field of ocular drug delivery.
Authors and Affiliations
Himanshu Pandey| Dept. of Pharmaceutical Sciences, Faculty of Health & Medical Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad- 211007, Uttar Pradesh, India, Upendra Kumar Sharma| Institute of Pharmacy, Bundelkhand University, Kanpur Road, Jhansi, Uttar Pradesh, India, Avinash C. Pandey| Nanotechnology Application Center, University of Allahabad, Allahabad- 211002, Uttar Pradesh, India
Keywords
Related Articles
- EP ID EP15976
- DOI -
- Views 414
- Downloads 25
Effect of Yogic exercise on static Spirometery values in normal healthy individuals
Introduction: Yogic practices can be a very good exercise for maintaining proper health and has a profound effect on the lung functions of an individual. They are also used as psycho-physiological stimuli to increase t...
EVALUATION OF ANTI-PROLIFERATIVE AND ANTIOXIDANT ACTIVITY OF SWERTIA CHIRATA: IMPLICATIONS IN BREAST CANCER
Background: Swertia chirata belonging to Gentianaceae family is a medicinal plant known to exhibit various pharmacological properties. Objective: This study investigates the antiproliferative effects of the aerial parts...
Speciation, biofilm formation and antifungal susceptibility of Candida isolates
Recently, an increase in the incidence of infections caused by fungi especially non-albicans Candida species has been reported. Several virulence factors like biofilm formation, toxin production and presence of adhesin...
Evaluation of Synergistic Anti-microbial efficacy of plant extracts and their formulation as Topical Agents
The objective of the present study was to evaluate the antimicrobial activity of Cassia fistula, Ficusreligiosa, Milletiapinnataand Wendlandiathyrsoideaand to check the synergistic efficacy of these extracts when combi...
ELECTRONIC TRIAL MASTER FILE (eTMF) - AN INDISPENSABLE TOOL THAT COLLECTS AND FILES ESSENTIAL DOCUMENTS OF A CLINICAL TRIAL: A REVIEW
Every organization involved in clinical trials in the BioPharma industry maintains a trial master file comprised of thousands of pages of regulatory documents required for each clinical trial. Managing thousands of clin...