A study on the effects of different surfactants on morphology and drug release of Repaglinide Microspheres
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2017, Vol 6, Issue 5
Abstract
Objectives: To rationalize the use of surfactants by preparing Repaglinide Microspheres using two types of Surfactants, Tween 80 and Span 80 and study their effects on different characteristics of the microspheres. Methods: The microspheres were produced by emulsion solvent evaporation method, using the Eudragit RS100, Ethylcellulose, Tween 80 and Span80. Results and discussion: The microspheres were free flowing in nature. The surfactant concentration was found to be greatly affected the microspheres size distribution and dissolution. Scanning Electron Microscopy was done to study the surface morphology of the microspheres. Results have indicated that the incorporation of hydrophilic surfactant (Tween 80) gave larger microspheres, where as incorporation of the hydrophobic surfactant (Span 80) gave smaller microspheres and hydrophilic surfactant containing microspheres had higher drug release rate compared to hydrophobic surfactant containing microspheres. Conclusion: Microspheres containing repaglinide was prepared successfully by using an emulsion solvent evaporation technique.
Authors and Affiliations
Vimal Kumar Yadav| Department of Pharmacy, Prasad Institute of Technology, Jaunpur, India, Awani Kumar Rai| Pranveer Singh Institute of Technology, Kanpur, India, A. K. Ghosh| Department of Pharmacy, IFTM University, Moradabad, India
Keywords
Related Articles
- EP ID EP16041
- DOI http://dx.doi.org/10.21276/IJRDPL.2278-0238.2017.6(5).2786-2
- Views 346
- Downloads 18
Birth Preparedness and Knowledge of ASHAs regarding danger signs of pregnancy in rural India: A cross sectional study
Background: Birth preparedness and complication readiness (BPCR) strategy based on the premise that preparing for childbirth reduces delays in obtaining timely, skilled maternal and neonatal care. Study was undertaken...
Pharmacognostic and phytochemical evaluation of Prunus persica (L.)
Objective: To evaluate the morphological, microscopical, physicochemical and phytochemical properties of leaves of P. persica. The study also represents the fingerprint profile of P. persica using high performance thin...
Synthesis and biological activity of some novel Combretastatin analogues and related compounds
CA-4 is a biologically very active compound by binding to the colchicine binding site which lead to the inhibition of microtubule polymerization as well as showing antiagiogenic and anticancer effects by selectively sh...
Production of Rifamycin using Nocardia mediterranea (ATCC 13865)
The U.V. irradiation to Nocardia mediterranea ATCC 13865 for 10, 20, 30, 40, 50, 60, 70, up to 120 minute the maximum (581µgml-1) production of rifamycin was found developed S-10 strain for maximum production of rifam...
Phytochemical analysis, exploration of antidiabetic and antioxidant potential of Anthocephalus cadamba (Roxb.)
The most common disease nowadays is diabetes. In a fast-changing world, many means to treat diabetes naturally are explored by experts and clinicians today. Continuing use of insulin and other oral hypoglycemic agent c...