A study on the effects of different surfactants on morphology and drug release of Repaglinide Microspheres
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2017, Vol 6, Issue 5
Abstract
Objectives: To rationalize the use of surfactants by preparing Repaglinide Microspheres using two types of Surfactants, Tween 80 and Span 80 and study their effects on different characteristics of the microspheres. Methods: The microspheres were produced by emulsion solvent evaporation method, using the Eudragit RS100, Ethylcellulose, Tween 80 and Span80. Results and discussion: The microspheres were free flowing in nature. The surfactant concentration was found to be greatly affected the microspheres size distribution and dissolution. Scanning Electron Microscopy was done to study the surface morphology of the microspheres. Results have indicated that the incorporation of hydrophilic surfactant (Tween 80) gave larger microspheres, where as incorporation of the hydrophobic surfactant (Span 80) gave smaller microspheres and hydrophilic surfactant containing microspheres had higher drug release rate compared to hydrophobic surfactant containing microspheres. Conclusion: Microspheres containing repaglinide was prepared successfully by using an emulsion solvent evaporation technique.
Authors and Affiliations
Vimal Kumar Yadav| Department of Pharmacy, Prasad Institute of Technology, Jaunpur, India, Awani Kumar Rai| Pranveer Singh Institute of Technology, Kanpur, India, A. K. Ghosh| Department of Pharmacy, IFTM University, Moradabad, India
Keywords
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- EP ID EP16041
- DOI http://dx.doi.org/10.21276/IJRDPL.2278-0238.2017.6(5).2786-2
- Views 367
- Downloads 18
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