Evaluating the Protective Impact of Ginger Extract Against Ciprofloxacin-Induced Hepatotoxicity in Male Albino rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2019, Vol 14, Issue 1
Abstract
In the present study, potential protective impact of ginger extract against ciprofloxacin (CPFX)- induced hepatotoxicity in male rats was investigated. Forty-two adult male albino rats were divided into seven groups: control, dimethyl sulphoxide (DMSO), ginger (200 mg/kg), CPFX20 (20 mg/kg), CPFX20 plus ginger, CPFX40 (40 mg/kg) and CPFX40 plus ginger. Both CPFX and ginger doses were orally given to rats for 10 consecutive days. At the end of the experiment, serum and liver samples were processed for biochemical assays. Obtained results exhibited that treatment of rats with CPFX produced marked increases in serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gammaglutamyl transferase (GGT) and total bilirubin. Also, CPFX markedly increased hepatic contents of malondialdehyde (MDA), protein carbonyl (PC), hydrogen peroxide (H2O2) and nitric oxide (NO). Meanwhile, the drug induced depletion in the hepatic levels of antioxidant parameters including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GRd) and glutathione-s-transferase (GST). In addition, CPFX induced apoptosis in the hepatic cells as indicated by increased level of p53 and caspase-3 accompanied with decreased level of Bcl-2. The deleterious effects of CPFX on all measured biochemical indices seemed to be dose-dependent. Concurrent treatment with ginger extract and CPFX in rats significantly mitigated the CPFX-induced oxidative stress and apoptosis, and greatly recovered the biomarkers of the hepatocellular injury. This study addressed, for the first time, that ginger extract may be useful in the protection against liver damage induced by CPFX. The hepatoprotective impact of ginger might be mediated primarily by its potent antioxidant activity and its ability to scavenge free radicals.
Authors and Affiliations
Faried A. E. Hemieda, Wafaa M. El- Kholy, Aysha S. Abdalmawla Masud
Keywords
Related Articles
- EP ID EP445302
- DOI 10.9790/3008-1401022330.
- Views 76
- Downloads 0
The impact of Immunotherapy on Ovarian Cancer
Ovarian cancer that estimated to be the top fifth leading cause of cancer death in women all over the world. Compelling evidence indicates that the immune response against ovarian cancer may play crucial role in controll...
A Study On Effect Of Pharmacist Mediated Patient Counseling In Hypertensive Patients In Terms Of Knowledge, Compliance And Quality Of Life.
To create awareness about hypertension in order to improve their quality of life. Free health camps were conducted; screening of blood pressure was done. Data were collected based on medical history, family history, food...
In vitro Growth Inhibition Study of Urinary Type Brushite Crystals in the Presence of Healthy Adult Urine and Tartaric acid
: Brushite or calcium hydrogen phosphate dehydrate is commonly found in urinary stones. In the present study the single diffusion gel growth technique was used to grow brushite crystals in silica hydro gel medium. It pro...
Effect of Different Growth Media on the Cell Densities of Freshwater Microalgae Isolates
The effect of BMM and BG-11 medium on the cell density of two economically important microalgal isolates (Chlorella sp. and Scenedesmus sp.) from Abakaliki fresh water body was investigated. The isolates were incubated i...
Germplasm Preservation And Propagation; The Foundation Of Agricultural Development –A Review
The whole set of genetic material of a species of plants is known as germplasm of the organisms. Through various breeding techniques the germplasm of various plant species can be stored or preserved for future plant deve...