“Evaluation Of Anti-Convulsant Activity Of Aqueous Extract Of Argyreia Nervosa Against Induce By Mes And Ptz Methods In Mice
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 1
Abstract
The present investigation was aimed to study an anticonvulsant activity of aqueous extract of Argyreia nervosa (family: convolvulaceae) in mice. Valuated the anti convulsant activity followed by two animal models: Maximal electroshock seizures induced seizure model and Pentylenetetrazole induced seizure model. Estimation was done by measuring decrease in the duration of HLTE induced by MES, when compared with the control group. AEAN at dose of 250 & 500 mg/kg p.o. showed reduction in HLTE and no mortality was found against MES induced convulsion. Phenytoin (25 mg/kg i.p.) significantly reduced the duration of MES-induced HLTE (***p<0.001) and completely prevented the various phases of convulsion induced by MES. PTZ (60 mg/kg, i.p.) produced convulsion in all the animals used. Mice pretreated with AEDT at the dose of 250 mg/kg p.o. not showed significant delay the onset of convulsion and duration of PTZ induced seizures in mice and reduced mortality to 66.7%. Similarly a dose of 500 mg/kg p.o. of AEDT significantly delayed the onset of convulsion (p<0.05), reduced the duration of convulsion (p<0.05) and not seen any mortality. Phytoconstituents like carbohydrates, flavonoids, proteins, saponins and tannins etc. AEAN at 500 mg/kg showed significant reduction of convulsions in PTZ induced petit mal epilepsy.
Authors and Affiliations
Lagu surendra babu, M. satti babu, ,CH. Suresh3, K. phani kumar
Keywords
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- EP ID EP383339
- DOI 10.9790/3008-11134550 .
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