EVALUATION OF ANTI-INFLAMMATORY ACTIVITY AND ANALGESIC EFFECT OF ALOE VERA LEAF EXTRACT IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
Clinical evaluation of analgesic and anti-inflammatory drugs envisages the development of side effects that makes efficacy of a drug arguable. Alternatively, indigenous drug with fewer side effects is the major thrust area of research in the management of pain and inflammation. In the present study aqueous extract of whole leaf of Aloe vera at various concentrations was investigated for its anti-inflammatory and analgesic activities in albino wistar rats. Carrageenan and formaldehyde-induced rat paw oedema was used to evaluate the anti-inflammatory activity and tail flick, hot plate and acetic acid tests were used to assess the analgesic activity of A. vera leaf aqueous extracts. Whole leaf aqueous extracts at various concentrations (100, 200, 400, and 600 mg/kg of bw) significantly reduced formation of oedema induced by carrageenan and formaldehyde and granuloma formation in a dose dependent manner. Further, acetic acid-induced writhing model exhibited significant analgesic effect characterized by reduction in writhes. Whole leaf aqueous extract showed dose-dependent increase in tolerance to thermal stimulus comparable to indomethacin. No mortality was observed during the acute toxicity test at a dosage of 600mg/kg. Thus whole leaf aqueous extract of Aloe vera can be exploited as non toxic drug for the treatment and clinical management of inflammation and pain.
Authors and Affiliations
Aruna Devaraj, Thirunethiran Karpagam
Keywords
Related Articles
- EP ID EP155818
- DOI -
- Views 82
- Downloads 0
DETERMINATION OF BIOACTIVE COMPONENTS OF MYXOPYRUM SERRATULUM A.W. HILL (OLEACEAE) STEM BY GC-MS ANALYSIS
The present study is to evaluate bioactive compounds of ethanol extract of Myxopyrum serratulum stem using GC-MS analysis. The chemical compositions of the ethanol extract of stem of Myxopyrum serratulum were investigate...
PROTECTIVE EFFICACY OF HUMBOLDTIA BRUNONIS WALL ON DOXORUBICIN INDUCED OXIDATIVE DAMAGE
Liver, heart and kidney are the frequent targets of the toxicants as liver involved in metabolism, heart supplies O2 to entire body and kidney involves in the excretion and re-absorption of the substances. The principle...
DEVELOPMENT AND EVALUATION OF PIROXICAM LOADED BIOPOLYMER BASED TRANSDERMAL FILM
The aim of the present study was to formulate biopolymer based transdermal film loaded with Piroxicam (PX). Transdermal films were prepared by using sodium locust bean gum (LBG) and Sodium alginate (SA) as biopolymers...
OVERVIEW OF INDIAN MEDICINAL TREE: BAMBUSA BAMBOS (DRUCE)
India has a great wealth of various naturally occurring plant drugs which have a great potential for pharmacological activities. Bambusa bambos family Graminae is highly reputed Ayurvedic medicinal tree commonly known as...
TRIGEMINAL NEURALGIA: AN OVERVIEW OF LITERATURE WITH EMPHASIS ON MEDICAL MANAGEMENT
Pain is a complex human psycho-physiological experience. Neuralgic pain is produced by a change in neurological structure or function rather than by the excitation of pain receptors that causes nociceptive pain. Neuralgi...