EVALUATION OF ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITY OF PUNICA GRANATUM SEED EXTRACT
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 12
Abstract
The plant Punica granatum of family Punicaceae is distributed throughout India and reputed to have numerous applications in traditional medicine system. In order to justify its folkloric use in nociception and inflammation, the study was performed. In this study, the extraction of Punica granatum seed extract was carried out in aqueous media. In order to explore its potency, various experimental models of anti-nociceptive and anti-inflammatory activities were taken. The oral administration of the extract 100mg and 200mg per kg body weight showed significant pharmacological action. Furthermore the anti-ulcer activity was carried out with the help of Indomethacin induced ulceration model using Mesoprostol as standard drug and it showed no ulcerogenic effect in wistar albino rats. Overall, the extract was found to be significant anti-nociceptive and anti-inflammatory activity with no ulcerogenic adverse effect.
Authors and Affiliations
Jeetendra Gupta , Sandeep Sharma , Vimlesh Misra , Kanika Patel
Keywords
Related Articles
- EP ID EP140264
- DOI -
- Views 90
- Downloads 0
STABILITY INDICATING HPTLC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF AMBROXOL HYDROCHLORIDE AND CETIRIZINE DIHYDROCHLORIDE IN COMBINE TABLET DOSAGE FORM
A new simple, sensitive and precise high performance thin layer chromatographic method has been developed for estimation of Ambroxol hydrochloride and Cetirizine dihydrochloride simultaneously from a combined Solid dosag...
ATROPHIC VAGINITIS
Atrophic vaginitis is a condition that arises when there is insufficient estrogen, resulting in a failure of the maturation of the vaginal epithelium. This is seen in any condition in which there is a significant decreas...
INVESTIGATION ON EFFECT OF THEVETIA PERUVIANA (PERS) ON THE MORTALITY OF HOLOTRICHIA SERRATA (FAB) ADULTS (COLEOPTERA: SCARABAIEDAE)
White grub is called as Chaffer beetle. White grub is a National pest, it has worldwide distribution. The white grub’s damage agricultural crops and there adults were feed on leaves of economical and medically important...
ENHANCEMENT OF SOLUBILITY BY COMPLEXATION WITH CYCLODEXTRIN AND NANOCRYSTALLISATION
The cyclodextrins have a wide range of applications in different areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. The most common pharmaceutical ap...
FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILMS OF GRANISETRON HYDROCHLORIDE USING DIFFERENT POLYMERS
GranisetronHydrochloride is an orally active, highly selective 5HT3 receptor antagonist used in the treatment of cancer chemotherapy induced nausea and vomiting. The present work aimed at preparing quick releasing films...