EVALUATION OF ANXIOLYTIC ACTIVITY OF CARUM COPTICUM BY USING ELEVATED PLUS MAZE AND OPEN FIELD METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 4
Abstract
The clinical applications of benzodiazepines as anxiolytics are limited by their unwanted side effects. Therefore, the development of new pharmacological agents is well justified. Among medicinal plants, Carum copticum has been recommended for relief of anxiety and insomnia in Iranian folk medicine. Nevertheless, no pharmacological studies have thus far evaluated its effects on central nervous system. Therefore, the aim of this study was to examine if the aqueous extract of Carum copticum seeds has anxiolytics effect in mice. The anxiolytic effect of aqueous extract (200, 400mg/kg) was examined in male albino mice using elevated plus-maze and open field as an animal model of anxiety. In the elevated plus-maze, aqueous extract at 200 mg/kg showed an anxiolytic effect by increasing the time spent on open arms and the percentage of open arm entries, compared to control group. These results suggest that the aqueous extract of Carum copticum seeds has anxiolytic effect.
Authors and Affiliations
SM Kharade , SS Khetmar , PS Desai , RS Lokhande , SS Patil
Keywords
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