PREFORMULATION STUDIES OF STAVUDINE FOR TARGETED DRUG DELIVERY SYSTEM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 9
Abstract
The aim of the present studywas the pre-formulation parameters of Stavudinefor targeted drug delivery system. Data generated from the pre-formulation study may be helpful to initiate the formulation development. The aim of the utilization of pre-formulation data is to maximize the possibilities in formulation for an appropriate, safe, efficacious and stable product and at the equivalent time offer the idea for optimization of the product quality.Stavudine is the nucleoside reverse transcriptase inhibitor usedfor the acquired immune deficiency syndrome with its oral bioavailability over 80%. The pre-formulation studies were conceded out on physiochemical property for the determination of physical appearance, melting point, solubility profile,partition coefficient and ultra-visiblespectrophotometer, infrared spectroscopy, differential scanning calorimetry,determination of quantitative estimation of drug. All the physiochemical data and results showed that the Stavudine could serve as an appropriate candidate drugfor targeted drug delivery system.
Authors and Affiliations
Girjesh Vishwakarma, Subhendu Mishra, Hemant Nagar
Keywords
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- EP ID EP153689
- DOI 10.7897/2230-8407.069125
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