Evaluation of Carrageenan induced anti-inflammatory activity of ethanolic extract of bark of Ficus virens Linn. in swiss albino mice
Journal Title: The Journal of Phytopharmacology - Year 2013, Vol 2, Issue 1
Abstract
The aim of the present study was to explore the probable anti-inflammatory activity of ethanolic extract of Ficus virens bark using Carrageenan induced inflammation in the mice. Swiss albino mice were treated orally with normal saline (as control group) and Ficus virens extract (200 and 400 mg/kg), 60 min before 0.1 mL 1% carrageenan injection. Paw volume was measured before and 1, 2, and 3 h after the injection of carrageenan. The results were expressed as the Mean ±SEM and the statistical significance of differences between groups was analyzed by One Way Analysis of Variance (ANOVA) followed by Dunnett’s test. The sub plantar injection of carrageenan caused a time-dependent paw edema in the mice. Oral administration of Ficus virens extract (200 and 400 mg/kg) inhibited paw swelling dose-dependently at 1, 2, and 3, h after Carrageenan injection. We can conclude from the outcome of the present work that Ficus virens extract exert an excellent anti-inflammatory effect in the mice.
Authors and Affiliations
Abdul Hafeez, Dr. Upendra Jain, Pinky Sajwan, Sirish Srivastava, Amit Thakur
Keywords
Related Articles
- EP ID EP49514
- DOI -
- Views 240
- Downloads 0
Protective effects of Centella asiatica against isoproterenol-induced myocardial infarction in rats: biochemical, mitochondrial and histological findings
Myocardial infarction (MI) induced by isoproterenol (ISO) is a standardized model to study the beneficial effects of different drugs. The protective effect of Centella asiatica on ISO-induced cardiotoxicity and the ant...
Anxiolytic activity of ethanolic extract of aerial parts of Tribulus terrestris in mice
Herbs have always been a preferred choice of treatment for people of the subcontinent and the Indo-Pak subcontinent has a long tradition of the use of herbs as medicines. In the given study ethanolic extract of Tribulu...
Cytotoxic activity of Acalypha indica L. hexane extract on breast cancer cell lines (MCF-7)
Cancer is the name given to a collection of related diseases. In all types of cancer, some of the body’s cells begin to divide without stopping and spread into surrounding tissues. Cancer can start almost anywhere in th...
Systemic evaluation of antibacterial activity of Anacardium occidentale
Background: Evaluation of antibacterial activity of different parts of two varieties of Anacardium occidentale L. tree {red fruited variety (RFV) and yellow fruited variety (YFV)}, namely, the fruit, leaf, stem bark an...
Amelioration of histological changes and associated metabolic abnormalities by a combination of Morinda lucida and metformin in diabetic rats
This work investigates the ability of Morinda lucida and co-administration of Morinda lucida/metformin in the control of biochemical and histological changes in alloxan-induced diabetic rats. Alloxan diabetic rats were...