EVALUATION OF GLYCOLIPIDS OF SOME EGYPTIAN MARINE ALGAE AS A SOURCE OF BIOACTIVE SUBSTANCES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
Glycolipids in five species of marine algae: two species of Rhodophyta (Laurencia popillose, Galaxoura cylindriea); and one species of Chlorophyta (Ulva fasciata), and two species of Phaeophyta (Dilophys fasciola, Taonia atomaria ) collected from Red and Mediterranean sea, respectively were extracted, purified on silica gel column chromatography and identified by liquid chromatography MS/MS. Total glycolipid contents (GL) (as % of total lipid) were found to be in ranges 10.9 to 28.7%. T. atomaria had the highest level (28.7%) followed by L. popillose (22.5 %). GL groups were analyzed for their sugars and fatty acids composition, and the result showed that the highest carbohydrate content of GLs were found in U. fasciata (6.05%) and L. popillose (5.8%), and characterized by high content of monosaccharide: mannouronic acid, galactose and rhamnose. Amongst of the glycolipids of algal species, the most predominate fatty acid identified by GC were palmatic (C16:0 19.20 - 65.89% of total fatty acid), ecosatrienoic (C20:3 7.52 - 54.41%). GL analyzed by LC/MS/MS, revealed the peak at m/z 956 corresponding to the molecular formula of C51H104O17 was the most abundant molecular ion among all GLs of algal species and its fragments peaks at m/z 617(C37H58O4) and m/z 337 (C21H58O3), were tentatively identified as digalactosyldiacylglycerol (DGDG). The in vitro anticancer, antimicrobial, and antiviral activities of algal glycolipids were evaluated. GL of all algae species showed a remarkable antiviral activity in dose dependent manner. GL from D. fasciola has shown the most potent effect against HSV1 (IC50 of 10 µg/ml), comparable to that of the current antiviral drug acyclovir (IC50 55 µg/ml). On the other hand, GL of all algal species possessed a moderate antimicrobial activity. GL of T. atomaria exhibited a high inhibition effects against all test microorganisms, with MIC value ranged from 60 to 80 µg/ml. Moreover, all algal GL exhibited remarkable anticancer activities against both breast (MCF7) and liver human (HepG2) cancer cells, with an IC50 values ranging from 0.47 to 2.89 µg/ml.
Authors and Affiliations
Gamal El Baroty , El-Baz , Farouk K , Abd-Elmoein Ibtisam, Abd El Hanaa H, Mohamed Ali , Eman Ibrahim
Keywords
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