Evaluation of Hepatic Enzymes in Uncomplicated Alcohol Withdrawal State and Alcohol Withdrawal State with Convulsions – A Comparative Study.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 6
Abstract
Alcoholism is a bio-psychosocial phenomenon par excellence; it is a result of combination of multiple individual and environmental risk factors. Severity of liver damage is often correlated with the amount of alcohol consumption in patients with a history of heavy alcohol abuse. Elevated liver enzymes are an important indicator of the same. The objective of the present study was to measure and compare Hepatic Enzymes in patients with uncomplicated alcohol withdrawal state with those alcohol withdrawal patients presenting with convulsions. The study was carried out in the Department of Psychiatry, Assam Medical College, Dibrugarh over a period of one year (2016-2017). It was a hospital based cross sectional and observational study with a total sample size of 60 in-patients (30 uncomplicated alcohol withdrawal cases and 30 cases of alcohol withdrawal state with convulsions). Cases were diagnosed as per ICD-10 guidelines and SPSS version 16.0 was used for statistical analysis of obtained data setting significance threshold at p<0.05. Gamma-Glutamyl Transferase (GGT) and Alanine Aminotransferase (ALT) activity were significantly raised in alcohol withdrawal patients with convulsions compared to patients with uncomplicated alcohol withdrawal state. There was however no significant difference in Aspartate Aminotransferase (AST) and Alkaline Phosphatase (ALP) activity between these two groups of patients. Raised Gamma-Glutamyl Transferase and Alanine Aminotransferase levels could be a risk factor for alcohol withdrawal seizures and may aid in the diagnosis and treatment of such patients.
Authors and Affiliations
Dr. Abhilekh Das
Keywords
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