EVALUATION OF HEPATOPROTECTIVE EFFECT OF ADIANTUM INCISUM FORSK LEAF EXTRACT AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
Oxidative damage is involved in the pathogenesis of various hepatic injuries. In the present study, the protectivity of methanolic extract of leaves of Adiantum incisum forsk (MEAI), as an antioxidant to protect against CCl4-induced oxidative stress and hepatotoxicity in Albino Wistar rats was investigated. Intraperitoneal injection of CCl4, produced a marked elevation in the serum levels of serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin, and decrease in the total protein. Histopathological analysis of the liver of CCl4-induced rats revealed marked liver cell necrosis with inflammatory collections that were conformed to increase in the levels of SOD, GPx, LPO and CAT. Daily oral administration of methanolic extract of A.incisum forsk at 100 and 200 mg/kg doses for 10 days produced a dose-dependent reduction in the serum levels of liver enzymes. Treatment with A.incisum forsk normalized various biochemical parameters of oxidative stress and was compared with standard Silymarin. Therefore, the results of this study show that A.incisum forsk can be proposed to protect the liver against CCl4-induced liver damage in rats, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenger effects.
Authors and Affiliations
Royal Frank, Suresh V , Arunachalam G , Kanthlal SK , Ziaudheen VM
Keywords
Related Articles
- EP ID EP155937
- DOI -
- Views 71
- Downloads 0
ANTICONVULSANT ACTIVITY OF MAHAKALAYANAKA GHRITA IN MAXIMAL ELECTRO-SHOCK AND PENTYLENETETRAZOLE INDUCED SEIZURES IN RATS
The present study was to evaluate the anticonvulsant activity of Maha Kalayanaka Ghrita on maximal electroshock (MES) and pentylenetetrazole (PTZ) induced seizures in rats. The ayurvedic formulation, Maha Kalayanaka Ghri...
ANTI-DIABETIC POTENTIAL OF DELONIX REGIA
Gulmohar (Delonix regia) is well known for its nutritional and medicinal properties in all over world. This research was undertaken to test the effect of gulmohar leaves extract on the diabetes of Rat. Gulmohar leaves ex...
QUANTITATIVE DETERMINATION OF SILDENAFIL CITRATE IN COMMERCIAL TABLET DOSAGE FORM MARKETED IN MAIDUGURI METROPOLITAN COUNCIL (MMC)
A quantitative analysis was carried out to determine the claimed content of sildenafil citrate present in commercial tablet dosage forms of different brands, using the reference standard from the developed method for ass...
ISOLATION OF TANNINS FROM CAESALPINIA CORIARIA AND EFFECT OF PHYSICAL PARAMETERS
The subject of the present work is the study of the influence of particle size temperature, methanol content and time on the extraction of tannins from caesalpinia coriaria by pressure autoclaving method. The determinati...
ROLE OF BETA LACTAMASES IN ANTIBIOTIC RESISTANCE: A REVIEW
Penicillin, the first β-lactam antibiotic was introduced into clinical practice in 1940s. Since then a large number of different β-lactam antibiotics including penicillins, cephalosporins, monobactam and carbapenems have...