RATIONALE OF DEPRESSION AND PURPOSE OF ANTIDEPRESSANT DRUGS: A REVIEW
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 6
Abstract
There is very vast empirical work that directly assesses the neurobiological association of neurochemicals and biochemical super factors with the liability to depression. Therefore, as a means of providing a framework for future research, this article outline the path physiology arises a consequence of altered regulation of particular brain chemicals. In addition, the present article reviews the evidence from both clinical and experimental studies which implicates rationale of depression and the mechanism from which antidepressant drug act for the maintenance of depressive illness. Present studies evolving rationale of the pathophysiology, catecholamine, Sleep alterations, Glucocorticoids, the Neurotrophic, Hypothyroidism, Emotionality and altered activity in depression and treatment of depression involves adaptation of neural systems. This rationale was based on a correlation of the psychological and cellular actions of a variety of psychotropic agents. This will be used as experimental tools to study pharmacological action of antidepressant drug.
Authors and Affiliations
Manisha Bhatti , Anjali Thakur
ANALGESIC EFFECT OF THE ETHANOLIC EXTRACT OF MORINGA OLEIFERA LINN. PLANT ON INDUCED ALBINO MICE
The ethanolic extract of whole part of Moringa oleifera plant in Eddy’s Hot plate method shows markedly increase in the pain threshold of mice. The three different Extract Curative doses of 100 mg/kg, 200 mg/kg and 400 m...
FORMULATION DEVELOPMENT AND EVALUATION OF DIDANOSINE SUSTAINED- RELEASE MATRIX TABLETS USING HPMC K100
The present investigation concerned with formulation design and evaluation of oral sustained release matrix tablets of Didanosine (DDI) prepared by direct compression method using various proportion of release retarding...
GASTRO PROTECTIVE EFFECTS OF FICUS DALHOUSIAE MIQ ROOTS ETHANOLIC EXTRACT IN INDOMETHACIN AND COLD RESTRAINT STRESS INDUCED ULCERS
The aim of the present study was to evaluate the gastro protective effects of FDREE in Indomethacin and cold restraint stress induced ulcer models. Wistar albino rats were employed in the study. The preliminary phytochem...
AN UPDATED OVERVIEW ON ATROPA BELLADONNA L.
Atropa belladonna L. (Family: Solanaceae; commonly known as belladonna, deadly nightshade, devil’s berries amongst others), a perennial herb (2n=72) is native of Europe, North Africa and Western Asia, possesses a long tr...
EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF ETHANOL EXTRACT OF POLYGALA JAVANA DC. WHOLE PLANT
The study was intended to evaluate the anti-inflammatory activity of the whole plant of Polygala javana. The anti-inflammatory activity study was carried out by using Carrageenan induced paw edema. The ethanol extract o...