Evaluation of in-vivo antiulcer activity of extracts from leaves of Pergularia Daemia (Forsk.) against ethanol induced ulcer in albino rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 3
Abstract
The ethanolic extracts of Pergularia daemia (Forsk.) was evaluated for its gastro-protective function on ethanol induced ulcer in albino rats. The leaves of Pergularia daemia was subjected to continuous hot percolation process. The acute toxicity studies revealed that LD50> 2000mg/kg for the extract. Pergularia daemia (Forsk) showed a dose dependent curative ratio compared to ulcer control groups. The values are statistically significant at two levels p<0.001, p<0.01. The EEPD exhibits antiulcer activity, which could be due to the presence of saponins or sugar-free polyphenols, and, thus, confirmed the traditional uses of Pergularia daemia (Forsk.) in the treatment of ulcers.
Authors and Affiliations
Karthik Dhananjayan, Varsha Venugopal, Pooja, Pulak Majumder
Keywords
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